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前列腺癌细胞系 22Rv1 和 DU145 来源的肿瘤异种移植物的饱和传递特性。

Saturation transfer properties of tumour xenografts derived from prostate cancer cell lines 22Rv1 and DU145.

机构信息

Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.

Medical Biophysics, University of Toronto, Toronto, ON, Canada.

出版信息

Sci Rep. 2020 Dec 4;10(1):21315. doi: 10.1038/s41598-020-78353-8.

DOI:10.1038/s41598-020-78353-8
PMID:33277574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7718243/
Abstract

Histopathology is currently the most reliable tool in assessing the aggressiveness and prognosis of solid tumours. However, developing non-invasive modalities for tumour evaluation remains crucial due to the side effects and complications caused by biopsy procedures. In this study, saturation transfer MRI was used to investigate the microstructural and metabolic properties of tumour xenografts in mice derived from the prostate cancer cell lines 22Rv1 and DU145, which express different aggressiveness. The magnetization transfer (MT) and chemical exchange saturation transfer (CEST) effects, which are associated with the microstructural and metabolic properties in biological tissue, respectively, were analyzed quantitatively and compared amongst different tumour types and regions. Histopathological staining was performed as a reference. Higher cellular density and metabolism expressed in more aggressive tumours (22Rv1) were associated with larger MT and CEST effects. High collagen content in the necrotic regions might explain their higher MT effects compared to tumour regions.

摘要

组织病理学目前是评估实体瘤侵袭性和预后的最可靠工具。然而，由于活检程序引起的副作用和并发症，开发用于肿瘤评估的非侵入性方法仍然至关重要。在这项研究中，饱和转移 MRI 用于研究源自前列腺癌细胞系 22Rv1 和 DU145 的小鼠异种移植瘤的微结构和代谢特性，这些细胞系表达不同的侵袭性。定量分析了与生物组织的微结构和代谢特性相关的磁化转移（MT）和化学交换饱和转移（CEST）效应，并比较了不同肿瘤类型和区域之间的差异。进行了组织病理学染色作为参考。侵袭性更高的肿瘤（22Rv1）中表达的更高细胞密度和代谢与更大的 MT 和 CEST 效应相关。坏死区域中高含量的胶原蛋白可能解释了它们与肿瘤区域相比更高的 MT 效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/0e9fd14b5a6d/41598_2020_78353_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/b45023b15c84/41598_2020_78353_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/f906ec549e6c/41598_2020_78353_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/db8ba61292f1/41598_2020_78353_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/e2965d77f49f/41598_2020_78353_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/daedc69d5e19/41598_2020_78353_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/8d4408d63758/41598_2020_78353_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/486e7fee7ef8/41598_2020_78353_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/b028bd42427a/41598_2020_78353_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/0e9fd14b5a6d/41598_2020_78353_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/b45023b15c84/41598_2020_78353_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/f906ec549e6c/41598_2020_78353_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/db8ba61292f1/41598_2020_78353_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/e2965d77f49f/41598_2020_78353_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/daedc69d5e19/41598_2020_78353_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/8d4408d63758/41598_2020_78353_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/486e7fee7ef8/41598_2020_78353_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/b028bd42427a/41598_2020_78353_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb4/7718243/0e9fd14b5a6d/41598_2020_78353_Fig9_HTML.jpg

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