Clinic of Reconstructive Dentistry, University of Zurich, Zurich, Switzerland.
Vetsuisse Faculty, Institute of Veterinary Pathology, Zurich, Switzerland.
J Clin Periodontol. 2021 May;48(5):721-733. doi: 10.1111/jcpe.13411. Epub 2021 Apr 4.
To analyse the soft tissue morphology under healthy and experimental mucositis conditions comparing zirconia and titanium implants.
Forty-two patients with two adjacent missing teeth received one zirconia (Zr) and one titanium (Ti) implant, with the mesial and distal position randomized. At 3 months, half of the patients were instructed to continue (healthy; h) and the other half to omit (experimental mucositis; m) oral hygiene around the implants for 3 weeks. Clinical parameters were evaluated before and after the experimental phase, and a soft tissue biopsy was harvested. Mixed model analyses were performed to analyse the data.
The plaque control record increased significantly for the two mucositis groups, reaching 68.3 ± 31.9% (mean ± SD) for Zr-m and 75.0 ± 29.4% for Ti-m (p < .0001), being also significantly lower for Zr-m than for Ti-m. Bleeding on probing remained stable in group Zr-m and amounted to 21.7 ± 23.6%, but increased significantly in group Ti-m (p = .040), measuring 32.5 ± 27.8%. The number of inflammatory cells and the length of the junctional epithelium did not significantly differ between the groups.
Both implants rendered similar outcomes under healthy conditions. Lower plaque and bleeding scores were detected for zirconia implants under experimental mucositis conditions. Histologically, only minimal differences were observed.
分析健康和实验性黏膜炎条件下氧化锆和钛种植体的软组织形态。
42 名有两颗相邻缺失牙的患者接受了一颗氧化锆（Zr）和一颗钛（Ti）种植体，近中和远中位置随机。3 个月时，一半患者被指示继续（健康；h），另一半患者被指示在 3 周内停止（实验性黏膜炎；m）对种植体周围的口腔卫生。在实验阶段前后评估临床参数，并采集软组织活检。采用混合模型分析进行数据分析。
两组黏膜炎患者的菌斑控制记录均显著增加，Zr-m 组达到 68.3±31.9%（平均值±标准差），Ti-m 组达到 75.0±29.4%（p<0.0001），Zr-m 组明显低于 Ti-m 组。Zr-m 组的探诊出血仍保持稳定，为 21.7±23.6%，但 Ti-m 组显著增加（p=0.040），为 32.5±27.8%。两组间炎症细胞数量和结合上皮长度无显著差异。
两种种植体在健康条件下均具有相似的结果。在实验性黏膜炎条件下，氧化锆种植体的菌斑和出血评分较低。组织学上观察到的差异很小。
