Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku 20520, Finland.
School of Medical Sciences, Örebro University, 702 81 Örebro, Sweden.
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Feb;1866(2):158857. doi: 10.1016/j.bbalip.2020.158857. Epub 2020 Dec 2.
Lipids have many important biological roles, such as energy storage sources, structural components of plasma membranes and as intermediates in metabolic and signaling pathways. Lipid metabolism is under tight homeostatic control, exhibiting spatial and dynamic complexity at multiple levels. Consequently, lipid-related disturbances play important roles in the pathogenesis of most of the common diseases. Lipidomics, defined as the study of lipidomes in biological systems, has emerged as a rapidly-growing field. Due to the chemical and functional diversity of lipids, the application of a systems biology approach is essential if one is to address lipid functionality at different physiological levels. In parallel with analytical advances to measure lipids in biological matrices, the field of computational lipidomics has been rapidly advancing, enabling modeling of lipidomes in their pathway, spatial and dynamic contexts. This review focuses on recent progress in systems biology approaches to study lipids in health and disease, with specific emphasis on methodological advances and biomedical applications.
脂质具有许多重要的生物学功能，如储能源、质膜的结构成分，以及代谢和信号通路中的中间物质。脂质代谢受到严格的体内平衡控制，在多个层次上表现出空间和动态的复杂性。因此，脂质相关的紊乱在大多数常见疾病的发病机制中起着重要作用。脂质组学被定义为生物系统中脂质组的研究，已成为一个快速发展的领域。由于脂质在化学和功能上具有多样性，如果要在不同的生理水平上解决脂质的功能，应用系统生物学方法是必不可少的。随着分析方法在生物基质中测量脂质的进展，计算脂质组学领域也在迅速发展，使脂质组在其途径、空间和动态背景下的建模成为可能。这篇综述重点介绍了系统生物学方法在健康和疾病中研究脂质的最新进展，特别强调了方法学的进展和生物医学的应用。
