Hassanpour Hossein, Mojtahed Marzieh, Fallah Aziz A, Jafari Tina
Department of Basic Sciences, Faculty of Veterinary Medicine Shahrekord University Shahrekord Iran.
Department of Cellular and Molecular Biology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences Islamic Azad University Tehran Iran.
Food Sci Nutr. 2024 Sep 15;12(11):8525-8539. doi: 10.1002/fsn3.4451. eCollection 2024 Nov.
The Lamiaceae plant family has a positive impact on metabolic diseases. This study meta-analyzed the data of different clinical trial studies on the impacts of these plants on blood lipid biomarkers including cholesterol, triglyceride, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). A comprehensive search was conducted using PubMed, Scopus, ISI Web of Science, ProQuest, Scientific Information Database, MagIran, and Google Scholar to identify relevant published research up to December 20, 2023. The meta-analysis revealed that the Lamiaceae family significantly reduced cholesterol ( < .001), triglyceride ( = .003), and LDL ( < .001) levels. The rise in HDL levels was not significantly impacted ( = .069). Subgroup studies revealed that Lamiaceae plants improve all lipid parameters for a short duration (≤8 weeks) while in a longer duration (>8 weeks) only LDL level is improved in the blood ( < .05). In addition, Lamiaceae plants specifically decreased LDL and cholesterol levels in diabetic patients and only LDL levels in the individuals who were hyperlipidemic or overweight/obese. Within the Lamiaceae family, the genera and had the most significant effects in decreasing triglyceride and LDL/cholesterol levels, respectively. was the only genus within the Lamiaceae family that significantly improved three lipid parameters (cholesterol, LDL, and HDL). The meta-analysis confirmed that Lamiaceae plants could improve the levels of lipid parameters (triglyceride, cholesterol, and LDL) in patients with metabolic syndrome.
唇形科植物家族对代谢性疾病有积极影响。本研究对不同临床试验研究的数据进行了荟萃分析，这些研究涉及这些植物对血脂生物标志物的影响，包括胆固醇、甘油三酯、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）。通过使用PubMed、Scopus、ISI Web of Science、ProQuest、科学信息数据库、MagIran和谷歌学术进行全面检索，以识别截至2023年12月20日已发表的相关研究。荟萃分析显示，唇形科植物显著降低了胆固醇（P<0.001）、甘油三酯（P=0.003）和低密度脂蛋白（P<0.001）水平。高密度脂蛋白水平的升高未受到显著影响（P=0.069）。亚组研究表明，唇形科植物在短时间内（≤8周）可改善所有血脂参数，而在较长时间（>8周）时，血液中仅低密度脂蛋白水平得到改善（P<0.05）。此外，唇形科植物特别降低了糖尿病患者的低密度脂蛋白和胆固醇水平，以及高脂血症或超重/肥胖个体的仅低密度脂蛋白水平。在唇形科植物家族中，[具体属1]属和[具体属2]属分别在降低甘油三酯和低密度脂蛋白/胆固醇水平方面具有最显著的效果。[具体属3]属是唇形科植物家族中唯一显著改善三项血脂参数（胆固醇、低密度脂蛋白和高密度脂蛋白）的属。荟萃分析证实，唇形科植物可改善代谢综合征患者的血脂参数（甘油三酯、胆固醇和低密度脂蛋白）水平。
