Latendresse J R, Campbell J R, Tirtokusumo S, Marwoto H A
Armed Forces Research Institute for Medical Sciences, Bangkok, APO San Francisco, CA 96346.
J Comp Pathol. 1987 Nov;97(6):653-65. doi: 10.1016/0021-9975(87)90077-6.
The discovery of the silvered leaf monkey, Presbytis cristata, as a suitable experimental host for the human filarial parasite, Wuchereria bancrofti, opened the door for major advances in our understanding of the disease caused by this parasite. To study the pathogenesis of bancroftian filariasis in this model, 15 adult P. cristata which had been experimentally infected with 250 infective third-stage larvae of the parasite were examined. After inoculation with larvae, the monkeys were maintained under study for periods of 2 to 3 years, at which time all had achieved patent infections. At necropsy, Wuchereria-induced macroscopic lesions were not detected in experimentally infected monkeys. Microscopic findings included nematodiasis, microfilariasis, lymphadenitis, lymphangiectasis, perilymphangitis, splenitis, orchitis, periorchitis, epididymitis and funiculitis. Sections of normal adult worms were most often found in lymphatic vessels near lymph nodes, or in the lymphatics of the male genital system. These worms caused microfiliariasis in some regional lymph nodes. Inflammatory responses to filariae were most prominent in proximity to degenerated and dead worms, whereas intact, normal appearing adult worms elicited only minimal cellular response.
银叶猴（Presbytis cristata）被发现是人体丝虫寄生虫班氏吴策线虫（Wuchereria bancrofti）的合适实验宿主，这为我们深入了解由该寄生虫引起的疾病打开了大门。为了在这个模型中研究班氏丝虫病的发病机制，对15只成年银叶猴进行了检查，这些猴子已被实验性感染了250条该寄生虫的感染性三期幼虫。接种幼虫后，将猴子饲养观察2至3年，此时所有猴子都出现了显性感染。尸检时，在实验感染的猴子中未检测到班氏吴策线虫引起的宏观病变。显微镜检查结果包括线虫病、微丝蚴血症、淋巴结炎、淋巴管扩张、淋巴管周围炎、脾炎、睾丸炎、睾丸周炎、附睾炎和精索炎。正常成虫的切片最常出现在淋巴结附近的淋巴管中，或男性生殖系统的淋巴管中。这些蠕虫在一些局部淋巴结中引起微丝蚴血症。对丝虫的炎症反应在退化和死亡的蠕虫附近最为明显，而完整、外观正常的成虫仅引起最小的细胞反应。
