Hospital Pharmacy Funen, Odense University Hospital, Odense C, Denmark; OPEN, Open Patient Data Explorative Network, Odense University Hospital, Odense C, Denmark; Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense C, Denmark.
Hospital Pharmacy Funen, Odense University Hospital, Odense C, Denmark.
Res Social Adm Pharm. 2021 Aug;17(8):1444-1452. doi: 10.1016/j.sapharm.2020.11.001. Epub 2020 Nov 4.
Knowledge about patients' attitudes towards deprescribing is essential for optimizing medication use. The revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire is a 22-item self-report instrument capturing older patients' beliefs and attitudes towards deprescribing.
To translate and cross-culturally adapt the rPATD questionnaire into Danish and subsequently validate it in a cohort of nursing home residents.
The rPATD questionnaire was translated and cross-culturally adapted during five stages of forward and backward translation. The validation study included 162 Danish nursing home residents (median age 84 years; 67% women). Validity was assessed through exploratory factor analysis (structural validity) and hypothesis testing (construct validity), while reliability was assessed through internal consistency. Floor and ceiling effects were examined.
The exploratory factor analysis revealed a 4-factor structure similar to the original rPATD questionnaire, with items loading into four factors related to level of involvement in medication use, perceived burden of taking medication, belief in appropriateness of using medication, and concerns about stopping medication. The questionnaire was adjusted to the Danish nursing home population and health care system by omission of two items, concerning medication expenses and inconvenience of taking medication, which resulted in a model with factor loadings ranging from 0.29 to 0.84 and only minor cross-loading. Construct validity correctly predicted 67% of the hypothesized correlations. Internal consistency of all factors was generally acceptable with Cronbach's α ranging from 0.67 to 0.78. No floor and ceiling effects were identified.
Results suggest that the Danish modified model of the rPATD questionnaire generally has acceptable validity and reliability.
了解患者对减药的态度对于优化药物使用至关重要。修订后的患者对减药的态度（rPATD）问卷是一种 22 项自我报告工具，用于捕捉老年患者对减药的信念和态度。
将 rPATD 问卷翻译成丹麦语，并随后在养老院居民中进行验证。
rPATD 问卷通过正向和反向翻译的五个阶段进行翻译和跨文化适应性调整。验证研究包括 162 名丹麦养老院居民（中位数年龄 84 岁；67%为女性）。通过探索性因素分析（结构有效性）和假设检验（构念有效性）评估有效性，同时通过内部一致性评估可靠性。还检查了地板和天花板效应。
探索性因素分析显示出与原始 rPATD 问卷相似的 4 因素结构，项目与四个因素相关，涉及参与药物使用的程度、服用药物的负担感知、对使用药物适当性的信念以及对停止药物的担忧。问卷通过省略与药物费用和服用药物不便相关的两个项目进行了调整，适用于丹麦养老院人群和医疗保健系统，调整后的模型具有从 0.29 到 0.84 的因子负荷，仅存在轻微的交叉负荷。构念有效性正确预测了 67%的假设相关性。所有因素的内部一致性通常可以接受，Cronbach's α 值在 0.67 到 0.78 之间。没有发现地板和天花板效应。
结果表明，丹麦 rPATD 问卷的修正模型通常具有可接受的有效性和可靠性。
