Hokonohara M, Yoshinaga M, Baba Y
Department of Nursing, School of Allied Medical Sciences, Kagoshima, Japan.
Jpn Circ J. 1987 Dec;51(12):1353-6. doi: 10.1253/jcj.51.1353.
Patients with rheumatic fever (RF) and Kawasaki disease (MCLS) were divided into two groups, one with and the other without cardiovascular lesions, and their sera were examined for antibodies to 4 streptococcal antigens: anti-streptococcal polysaccharide (ASP), anti-deoxyribonuclease B (ADN-B), anti-streptolysin O (ASO) and anti-streptokinase (ASK) in order to clarify the relationship between group A streptococci and these two diseases. In RF the frequency of positive levels of ASP at its early stage was lower than those of the other 3 antibodies, but the ASP titer tended to persist at elevated levels. The frequency of ADN-B in patients with rheumatic heart disease (RHD) was higher than that in those without RHD, but with regard to the other antibodies no difference was found between the two. Of the 4 antibodies the frequency of at least one positive level was 100% in all the sera of RF patients within 3 months from onset. The differences in the frequencies of positive levels of all 4 antibodies in both MCLS and the controls did not prove to be significant. The frequencies of ASP, ADN-B and ASO in the sera of patients without cardiovascular lesions tended to be slightly higher than those in patients with cardiovascular lesions.
风湿热（RF）和川崎病（MCLS）患者被分为两组，一组有心血管病变，另一组无心血管病变，并检测他们血清中针对4种链球菌抗原的抗体：抗链球菌多糖（ASP）、抗脱氧核糖核酸酶B（ADN - B）、抗链球菌溶血素O（ASO）和抗链激酶（ASK），以阐明A组链球菌与这两种疾病之间的关系。在RF中，ASP早期阳性水平的频率低于其他3种抗体，但ASP滴度往往持续处于升高水平。风湿性心脏病（RHD）患者中ADN - B的频率高于无RHD的患者，但就其他抗体而言，两者之间未发现差异。在发病后3个月内，RF患者所有血清中至少一种阳性水平的4种抗体的频率均为100%。MCLS组和对照组中所有4种抗体阳性水平的频率差异均无统计学意义。无心血管病变患者血清中ASP、ADN - B和ASO的频率往往略高于有心血管病变的患者。
