Department of Laboratory Medicine and Pathology, Hennepin County Medical Center of Hennepin Healthcare and University of Minnesota, Minneapolis, MN.
Medical and Scientific Affairs - POC, Roche Diagnostics Corporation, Indianapolis, IN.
Clin Chem. 2021 Jan 8;67(1):70-78. doi: 10.1093/clinchem/hvaa264.
The primary role of the International Federation of Clinical Chemistry (IFCC) Committee on Clinical Application of Cardiac Bio-Markers (C-CB) is to provide educational materials about cardiac biomarker use, emphasizing high-sensitivity cardiac troponin assays.
This mini-review, regarding high-sensitivity cardiac and point-of-care troponin assays, addresses 1) new IFCC C-CB/AACC Academy laboratory practice recommendations; 2) new and updated concepts from the Fourth Universal Definition of Myocardial Infarction; 3) the role of point-of-care assays in practice and research; 4) regulatory challenges concerning point-of-care assays; e) testing in the COVID-19 world.
Implementation of high-sensitivity cardiac troponin assays makes a difference now and into the future in clinical practice and research. Providing point-of-care high-sensitivity cardiac troponin assays and optimizing studies to allow clearance of these assays by regulatory agencies, in a timely fashion, may provide improved patient management and outcomes.
国际临床化学联合会（IFCC）临床应用心脏生物标志物委员会（C-CB）的主要职责是提供有关心脏生物标志物使用的教育材料，重点是高敏心肌肌钙蛋白检测。
这篇迷你综述主要介绍了高敏心肌和即时检测（POC）心肌肌钙蛋白检测，内容涵盖：1）IFCC C-CB/AACC 学院实验室实践推荐的新内容；2）第四版心肌梗死通用定义的新概念；3）POC 检测在实践和研究中的作用；4）POC 检测的监管挑战；5）新冠疫情下的检测。
高敏心肌肌钙蛋白检测的应用在当下和未来的临床实践和研究中都具有重要意义。现在，提供即时检测高敏心肌肌钙蛋白检测，并优化研究，以便及时通过监管机构审批这些检测，可能会改善患者的管理和预后。
