Goldberg Aaron, McGrath Samuel, Marber Michael
Stoke Mandeville Hospital, Aylesbury HP21 8AL, UK.
BHF Centre of Research Excellence, The Rayne Institute, King's College London, 4th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
J Clin Med. 2024 Dec 12;13(24):7570. doi: 10.3390/jcm13247570.
Laboratory-based high-sensitivity cardiac troponin testing has been the pillar for emergency stratification of suspected acute coronary syndrome for well over a decade. Point-of-care troponin assays achieving the requisite analytical sensitivity have recently been developed and could accelerate such assessment. This review summarises the latest assays and describes their potential diverse clinical utility in the emergency department, community healthcare, pre-hospital, and other hospital settings. It outlines the current clinical data but also highlights the evidence gap, particularly the need for clinical trials using whole blood, that must be addressed for safe and successful implementation of point-of-care troponin analysis into daily practice. Additionally, how point-of-care troponin testing can be coupled with advances in biosensor technology, cardiovascular screening, and triage algorithms is discussed.
十多年来，基于实验室的高敏心肌肌钙蛋白检测一直是疑似急性冠状动脉综合征急诊分层的支柱。最近已开发出达到所需分析灵敏度的即时检测肌钙蛋白检测方法，这可能会加速此类评估。本综述总结了最新的检测方法，并描述了它们在急诊科、社区医疗、院前和其他医院环境中潜在的多种临床用途。它概述了当前的临床数据，但也强调了证据差距，特别是需要进行使用全血的临床试验，这是将即时检测肌钙蛋白分析安全、成功地应用于日常实践所必须解决的问题。此外，还讨论了即时检测肌钙蛋白检测如何与生物传感器技术、心血管筛查和分诊算法的进展相结合。
