Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant'Orsola-Malpighi, Bologna, Italy.
Int J Dermatol. 2021 Aug;60(8):933-943. doi: 10.1111/ijd.15301. Epub 2020 Dec 6.
Terra firma-forme dermatosis (TFFD) is an acquired pigmentation disorder that promptly regresses after applying isopropyl alcohol 70%. The clinical presentation ranges from patches of brownish discoloration to velvety hyperkeratotic plaques. Critical analyses of current data are lacking, so etiologies, pathogenesis, and disease associations are still debated in the literature. A literature search was done in the PubMed and Google Scholar databases to identify the published papers reporting clinical cases of TFFD. Of 102 papers screened, 64 met the including criteria. Overall, the records of 256 patients presenting a mean age of 18.34 years and a female:male ratio of 1:37 were reviewed. The present article aims to provide a key point-summary regarding the clinical outcome, associated comorbidities, pathogenesis, histopathology, dermoscopy, and therapeutic modalities of TFFD.
地坚实型皮肤病（TFFD）是一种获得性色素沉着障碍，在应用 70%异丙醇后会迅速消退。临床表现从褐色色素沉着斑到天鹅绒状过度角化斑块不等。目前缺乏对现有数据的批判性分析，因此病因、发病机制和疾病相关性在文献中仍存在争议。在 PubMed 和 Google Scholar 数据库中进行了文献检索，以确定报告 TFFD 临床病例的已发表论文。在筛选出的 102 篇论文中，有 64 篇符合纳入标准。总体而言，回顾了 256 名平均年龄为 18.34 岁、女性与男性比例为 1:37 的患者的记录。本文旨在提供关于 TFFD 的临床结果、相关合并症、发病机制、组织病理学、皮肤镜检查和治疗方式的要点总结。
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