Department of Surgical Oncology, Ankara City Hospital, Ankara, Turkey.
Department of General Surgery, Usak Research and Training Hospital, Usak, Turkey.
Int J Clin Pract. 2021 Apr;75(4):e13897. doi: 10.1111/ijcp.13897. Epub 2020 Dec 17.
The aim of this study is to evaluate the relation between LVI and molecular subtypes in invasive breast cancers and to find out whether LVI which is a histopathologic indicator has a role in subtype classification or not.
One hundred and seventy-six patients who had mastectomy for breast cancer between 2013 and 2018 in the Department of Surgical Oncology, Faculty of Medicine, Ankara University were retrospectively analysed. One hundred and thirty-two patients who had LVI, ER, PR, Her 2 and Ki-67 index status information provided in their pathology results were included in the study. The relationship between molecular subtypes and LVI was investigated.
One hundred and thirty-two patients were analysed retrospectively. Eighty-two patients had LVI and 50 patients had not. We found a relationship between Luminal B with Her2(-) and LVI, basal like and LVI (P = .00). No significant statistical difference was found between LVI and other molecular subtypes. We confirmed these results with multiple variable analysis (%77.3 correlation).
As a result, we found that LVI can affect molecular subtypes. This showed that a histopathological factor may affect tumour biology. In other words, breast cancer is a heterogeneous disease with many different predictors and prognostic variables.
本研究旨在评估脉管内浸润（LVI）与浸润性乳腺癌分子亚型之间的关系，并探讨作为组织病理学指标的 LVI 是否在亚型分类中具有作用。
回顾性分析 2013 年至 2018 年期间在安卡拉大学医学院外科肿瘤学系行乳腺癌乳房切除术的 176 例患者。在病理结果中提供 LVI、ER、PR、Her 2 和 Ki-67 指数状态信息的 132 例患者被纳入本研究。研究调查了分子亚型与 LVI 之间的关系。
对 132 例患者进行了回顾性分析。82 例患者有 LVI，50 例患者无 LVI。我们发现 LVI 与 Luminal B 伴 Her2(-)和基底样与 LVI 之间存在关系（P=0.00）。LVI 与其他分子亚型之间未发现显著的统计学差异。我们用多变量分析（77.3%的相关性）证实了这些结果。
因此，我们发现 LVI 可能影响分子亚型。这表明组织病理学因素可能影响肿瘤生物学。换句话说，乳腺癌是一种具有许多不同预测因子和预后变量的异质性疾病。
