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醚脂类的生物合成与生物转化

Biosynthesis and biotransformation of ether lipids.

作者信息

Mangold H K, Weber N

机构信息

Federal Center for Lipid Research, H.P. Kaufmann-Institute, Münster, Federal Republic of Germany.

出版信息

Lipids. 1987 Nov;22(11):789-99. doi: 10.1007/BF02535533.

Abstract

Some naturally occurring as well as synthetic ether lipids are biologically active. In certain cases, the effects of these substances are enhanced, in others, they are inhibited by compounds that were isolated from natural sources or prepared by chemical synthesis. The biotransformation of natural or "unnatural" ether lipids in microorganisms, plant or animal tissue also can lead to substances that elicit biological effects. The production of such compounds through various biotechnological techniques is a field wide open for future exploration. In addition to animal cell cultures, plant cell cultures may become useful tools in biomedical studies concerned with ether lipids.

摘要

一些天然存在的以及合成的醚脂具有生物活性。在某些情况下,这些物质的作用会增强,而在其他情况下,它们会被从天然来源分离或通过化学合成制备的化合物所抑制。微生物、植物或动物组织中天然或“非天然”醚脂的生物转化也可能产生具有生物效应的物质。通过各种生物技术生产此类化合物是一个有待未来探索的广阔领域。除动物细胞培养外,植物细胞培养可能成为与醚脂相关的生物医学研究中的有用工具。

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