Majidova Y N, Khaidarova D K, Khojaeva D T
Tashkent Medical Pediatric Institute, 223 Bogishamol str., Tashkent 100140, Republic of Uzbekistan, e-mail:
Bukhara State Medical Institute, 1 Navoi pr., Bukhara 200118, Republic of Uzbekistan.
Adv Gerontol. 2020;33(3):496-500.
The effectiveness of neurometabolic therapy in patients with various stages of discirculatory encephalopathy was assessed according to the severity of cognitive impairment. Using a number of studies [clock drawing test, MMSE, Spielberger-Hanin, Bourdon test and cognitive evoked potentials (P300 peak)], cognitive functions of 60 elderly patients (mean age - 61,3±12,4 years) with various degrees of chronic head ischemia were analyzed brain and discirculatory encephalopathy of the I-III stages. Depending on the treatment regimen, patients were divided into 2 groups: 34 (the main group) received Cytoflavin in the treatment regimen: 2 tablets 2 times/day for 2 months. The comparison group consisted of 26 patients who received basic therapy without Cytoflavin. The majority (81,7%) of patients revealed cognitive disorders of varying severity. The inclusion of Cytoflavin in the treatment regimen improved the performance of neuropsychological tests (concentration and stability of attention, memory indicators, decreased reactive anxiety and smoothing signs of dementia), as evidenced by the positive dynamics of the CVP test (shortening the latency period and increasing the amplitude of the P300 peak, and as a result, reducing the coefficient latency / amplitude ratios).
根据认知障碍的严重程度，评估了神经代谢疗法对不同阶段循环障碍性脑病患者的疗效。通过多项研究[画钟试验、简易精神状态检查表（MMSE）、斯皮尔伯格 - 哈宁测试、布尔登测试和认知诱发电位（P300波峰）]，分析了60例患有不同程度慢性脑缺血且处于I - III期脑循环障碍性脑病的老年患者（平均年龄 - 61.3±12.4岁）的认知功能。根据治疗方案，将患者分为2组：34例（主要组）在治疗方案中接受细胞色素C：2片，每日2次，共2个月。对照组由26例接受不含细胞色素C的基础治疗的患者组成。大多数（81.7%）患者表现出不同程度的认知障碍。治疗方案中加入细胞色素C改善了神经心理学测试的表现（注意力的集中和稳定性、记忆指标、反应性焦虑降低以及痴呆症状减轻），认知诱发电位测试（CVP）的积极动态变化证明了这一点（缩短潜伏期并增加P300波峰的幅度，结果降低潜伏期/幅度系数比）。
