Health Examination Center and Department of Radiology, China Medical University Hospital, Taichung, Taiwan.
Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
Acta Radiol. 2021 Dec;62(12):1618-1624. doi: 10.1177/0284185120975180. Epub 2020 Dec 6.
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) plays a significant role in tumor stage as it can be used to measure tissue perfusion and permeability of tumors.
To investigate the relationships between both quantitative and semi-quantitative variables obtained from DCE-MRI and tongue cancer stages.
Mean values of K, enhancement ratio (ER), wash-in slope (slope), and the 95th percentile (95%) values of the distribution for K, ER, and slope values (K (95%), ER (95%), and slope (95%), respectively) were calculated for 53 patients with tongue cancers (American Joint Committee on Cancer 8th Edition stage group: 10 in stages I and II, 14 in stage III, 21 in stage IVa, and eight in stage IVb as determined by histopathologic assessment). The relationship between tumor staging and each of the six DCE-MRI parameters was assessed separately using ordinal logistic regression.
The logistic regression analysis revealed that both mean and 95th percentile values of K were significantly and positively correlated with tongue cancer stage ( < 0.01). More aggressive tumor stages had larger kinetic parameter. Moreover, the semi-quantitative parameters, such as ER (95%) and slope (95%), may be more significant predictors for evaluating tongue cancer stages than the mean ER and mean slope.
Both quantitative and semi-quantitative imaging biomarkers are useful for evaluating the stages of tongue cancer, and the indices obtained from DCE-MRI were positively correlated with the tumor stages. These parameters have the potential to non-invasively evaluate the stages of tongue cancer in the clinical setting.
动态对比增强磁共振成像（DCE-MRI）在肿瘤分期中具有重要作用，因为它可用于测量肿瘤组织的灌注和通透性。
探讨 DCE-MRI 获得的定量和半定量变量与舌癌分期之间的关系。
对 53 例舌癌患者（美国癌症联合委员会第 8 版分期组：组织病理学评估确定的 I 期和 II 期 10 例、III 期 14 例、IVA 期 21 例和 IVB 期 8 例）的 DCE-MRI 参数进行计算，包括 K、增强比（ER）、斜率（slope）的平均值以及 K、ER 和 slope 值的第 95 百分位数（分别为 K（95%）、ER（95%）和 slope（95%））。使用有序逻辑回归分别评估肿瘤分期与六个 DCE-MRI 参数之间的关系。
逻辑回归分析显示，K 的平均值和第 95 百分位数均与舌癌分期呈显著正相关（ < 0.01）。侵袭性较高的肿瘤分期具有更大的动力学参数。此外，半定量参数，如 ER（95%）和 slope（95%），可能比平均 ER 和平均 slope 更能显著预测评估舌癌分期。
定量和半定量成像生物标志物均可用于评估舌癌分期，DCE-MRI 获得的指数与肿瘤分期呈正相关。这些参数具有在临床环境中无创评估舌癌分期的潜力。
