Rheumatology Immunology, Weifang People's Hospital, Weifang, Shandong 261000, China.
Internal Medicine-Cardiovascular Department, Weifang People's Hospital, Weifang, Shandong 261000, China.
Contrast Media Mol Imaging. 2022 Jun 21;2022:3055465. doi: 10.1155/2022/3055465. eCollection 2022.
In order to solve the application problem of dynamic contrast-enhanced MRI in the diagnosis of rheumatoid arthritis, this paper proposes application research based on dynamic contrast-enhanced MRI in the staging diagnosis of rheumatoid arthritis. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has a high value in evaluating the activity of patients with early rheumatoid arthritis (RA). This paper discusses the correlation between hemodynamic parameters and omeractramris score, clinical laboratory indexes, and activity score (DAS28), analyzes its feasibility in evaluating the prognosis of RA, and provides a reliable basis for the rational formulation of an early RA treatment plan. After reviewing the previous cases, 33 patients with subclinical synovitis of RA were selected for wrist joint contrast-enhanced ultrasonography. The data were analyzed by contrast-enhanced software, and the quantitative parameters of contrast-enhanced were obtained: start development time (AT), peak time (TTP), peak intensity (PI), grad gradient, and area under the curve (AUC). The synovial blood supply was classified by CEUS, and the CEUS blood supply classification and power Doppler (PDUS) blood supply classification were compared. The results of regression analysis showed that AUC (or = 1.026, 95% CI: 1.001-1.052) and PI (or = 1.561, 95% CI: 1.019-2.393) were independent risk factors for predicting the aggravation of the disease. The diagnostic efficacy of AUC and PI in predicting the aggravation of the disease was analyzed. The areas under the ROC curve of AUC and PI were 0.935 and 0.927, respectively, and the difference between them was not statistically significant.
为解决动态对比增强磁共振成像（DCE-MRI）在类风湿关节炎（RA）诊断中的应用问题，本研究基于 DCE-MRI 在 RA 分期诊断中的应用进行了相关研究。动态对比增强磁共振成像（DCE-MRI）在评估早期类风湿关节炎（RA）患者的疾病活动度方面具有较高的应用价值。本文探讨了血流动力学参数与 OMERACT-ramris 评分、临床实验室指标及活动评分（DAS28）的相关性，分析了其在评估 RA 预后中的可行性，为制定早期 RA 治疗方案提供了可靠的依据。回顾性分析了 33 例腕关节滑膜炎症的亚临床 RA 患者，对其行腕关节超声造影检查，采用对比增强软件对其数据进行分析，获得对比剂增强的定量参数：开始增强时间（AT）、达峰时间（TTP）、峰值强度（PI）、斜率梯度、曲线下面积（AUC）。采用 CEUS 对滑膜血供进行分级，并比较 CEUS 血流分级与能量多普勒超声（PDUS）血流分级的相关性。回归分析结果显示 AUC（或 = 1.026，95%CI：1.001-1.052）和 PI（或 = 1.561，95%CI：1.019-2.393）是预测疾病加重的独立危险因素。分析 AUC 和 PI 预测疾病加重的诊断效能，AUC 和 PI 的 ROC 曲线下面积分别为 0.935 和 0.927，差异无统计学意义。
