Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan.
Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
Nat Prod Res. 2022 Feb;36(4):961-966. doi: 10.1080/14786419.2020.1855169. Epub 2020 Dec 7.
L., an important member of family Ranunculaceae upon submission to phytochemical studies, led to the isolation of a novel natural hydrazine derivative, muricazine (). Chemical structure of the compound was established with the aid of advanced spectroscopic techniques. It was evaluated for antioxidant, lipoxygenase, and urease (jack-bean) inhibitory activities. Results suggested that compound could scavenge the DPPH free radical (42.1 ± 0.12 M) to a great extent as compared to the standard (40.6 ± 0.91 M). However, it showed moderate inhibitory potential against lipoxygenase (65.2 ± 0.45 M) and urease (54.8 ± 0.23 M) enzymes.
L.，毛茛科的重要成员，经过植物化学研究，导致了一种新型天然肼衍生物的分离，即 muricazine（）。化合物的化学结构是借助先进的光谱技术确定的。它被评估了抗氧化、脂氧合酶和脲酶（豇豆）抑制活性。结果表明，与标准品（40.6±0.91M）相比，化合物可以极大地清除 DPPH 自由基（42.1±0.12M）。然而，它对脂氧合酶（65.2±0.45M）和脲酶（54.8±0.23M）的抑制活性适中。
