Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur 495 009, C.G., India.
Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia.
Mini Rev Med Chem. 2021;21(8):1004-1016. doi: 10.2174/1389557520666201204162103.
The novel coronavirus disease-19 (COVID-19) is a global pandemic that emerged from Wuhan, China, and has spread all around the world, affecting 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 updates of August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine exists. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID- 19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in clinical uses or studies on COVID-19 and also focuses on the mode of action of drugs being repositioned against COVID-19.
新型冠状病毒病-19（COVID-19）是一种全球性大流行疾病，源自中国武汉，现已蔓延至世界各地，影响了全球 216 个国家或地区，感染人数达 21732472 人，全球死亡人数达 770866 人（截至 2020 年 8 月 18 日世界卫生组织 COVID-19 更新数据）。目前正在不断努力重新利用现有药物并开发疫苗来对抗这种感染。尽管迄今为止尚无经认证的抗病毒治疗方法或疫苗。尽管如此，一些候选药物在体外研究中已显示出疗效，并被重新用于 COVID-19 的治疗。本文总结了在 COVID-19 临床应用或研究中显示出强大活性的合成和半合成化合物，并重点介绍了针对 COVID-19 重新定位药物的作用模式。
