Third Department of Pediatrics, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Third Department of Pediatrics, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Vaccine. 2021 Mar 5;39(10):1481-1484. doi: 10.1016/j.vaccine.2020.11.061. Epub 2020 Dec 3.
Measles outbreaks pose significant risk for those unvaccinated.
Measles-containing vaccine was offered to unvaccinated children with severe neurologic diseases during a measles outbreak. Vaccination adverse events were reported by parents 30 days following vaccination. Long term effects were evaluated 12 months post vaccination.
Twenty-seven children were vaccinated (36 doses given). Half of parents (51.8%) reported no adverse events following immunization. Adverse events included afebrile seizures (6/36), fever alone (5/36) and febrile seizures (5/36). Two children required hospitalization. Quadrivalent measles-containing vaccine combined with varicella was associated with febrile seizures (p = 0.04). No child needed adjustment of the anti-epileptic treatment or exhibited developmental regression.
Ina series of children with prior severe neurologic disease, the safety-tolerability profile ofvaccines containing a measles vaccine component suggests that vaccination is justified. Main side effect was seizure aggravation in children with known epileptic disease.
麻疹暴发对未接种疫苗的人构成重大风险。
在麻疹暴发期间，为患有严重神经疾病的未接种疫苗儿童提供含麻疹疫苗。父母在接种疫苗后 30 天报告接种疫苗的不良反应。接种疫苗 12 个月后评估长期效果。
27 名儿童接受了疫苗接种（共接种 36 剂）。一半的父母（51.8%）报告接种疫苗后没有不良反应。不良反应包括无热惊厥（6/36）、单纯发热（5/36）和热性惊厥（5/36）。有 2 名儿童需要住院治疗。含四价麻疹的疫苗联合水痘疫苗与热性惊厥有关（p=0.04）。没有孩子需要调整抗癫痫治疗或出现发育倒退。
在一系列既往有严重神经疾病的儿童中，含有麻疹疫苗成分的疫苗的安全性和耐受性表明接种疫苗是合理的。已知患有癫痫疾病的儿童的主要副作用是癫痫发作加重。
