A clinical study on (therapeutic purgation) over the gut flora with special reference to obesity.

BACKGROUND

Altered gut flora is associated with the pathogenesis of both intestinal and extra‑intestinal disorders. Aetiology of obesity is associated with mechanisms such as short chain fatty acid production, stimulation of hormones, chronic low‑grade inflammation, lipoprotein and bile acid metabolism and increased endocannabinoid. Receptor system tone have been suggested to explain the role of gut microbiota of obesity. The (Ayurvedic purification methods) claims the management of metabolic disorders hence this work provides the target specific evidence for the clinical studies. The proposed project is aimed to explore the particular molecular mechanism and, to make this therapy more evidence based. Hence, it was hypothesized that ‑based intervention such as (therapeutic purgation) may influence microbiota and help in the management of the obesity.

MATERIALS AND METHODS

The study was conducted to explore the effect of over the gut flora; therefore, total of 19 patients with diagnosed with obesity were included and received the intervention. Before and after , a stool sample was collected and processed for the enterobacterial repetitive intergenic consensus ‑polymerase chain reaction to find the changes over the facultative aerobic bacteria.

RESULTS

It was found that is effective in the management of the obesity as it helps to reduce colonization of aerobic bacteria. After and after follow‑up also, it showed the correction of the gut flora dysbiosis, thus initiated the weight loss mechanism in the body, resulting in diminution in the signs and symptoms of obesity.

CONCLUSION

is effective in the management of the obesity due to reduction in the colonization and is effective over the gut flora dysbiosis.