Bio Environmental Health Hazards Research Center, Jiroft University of Medical Sciences, Jiroft, Iran.
Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran.
Mol Biol Rep. 2024 Aug 31;51(1):945. doi: 10.1007/s11033-024-09850-6.
Neurodegenerative diseases are characterized by progressive memory impairment and cognitive decline. This review aims to unravel the molecular mechanisms involved in the enhancement of memory function and mitigation of memory impairment through the activation of PPARγ agonists in neurodegenerative diseases. The findings suggest that PPARγ agonists modulate various molecular pathways involved in memory formation and maintenance. Activation of PPARγ enhances synaptic plasticity, promotes neuroprotection, suppresses neuroinflammation, attenuates oxidative stress, and regulates amyloid-beta metabolism. The comprehensive understanding of these molecular mechanisms would facilitate the development of novel therapeutic approaches targeting PPARγ to improve memory function and ultimately to alleviate the burden of neurodegenerative diseases. Further research, including clinical trials, is warranted to explore the efficacy, safety, and optimal use of specific PPARγ agonists as potential therapeutic agents in the treatment of memory impairments associated with neurodegenerative diseases.
神经退行性疾病的特征是进行性记忆障碍和认知能力下降。本综述旨在揭示通过激活神经退行性疾病中的过氧化物酶体增殖物激活受体γ（PPARγ）激动剂来增强记忆功能和减轻记忆障碍的分子机制。研究结果表明，PPARγ 激动剂调节参与记忆形成和维持的各种分子途径。激活 PPARγ 可增强突触可塑性、促进神经保护、抑制神经炎症、减轻氧化应激和调节淀粉样蛋白-β代谢。全面了解这些分子机制将有助于开发针对 PPARγ 的新型治疗方法，以改善记忆功能，最终减轻神经退行性疾病的负担。需要进一步的研究，包括临床试验，以探索特定的 PPARγ 激动剂作为治疗与神经退行性疾病相关的记忆障碍的潜在治疗剂的疗效、安全性和最佳使用方法。
