Gungor Sukru, Köylü Ahmet Alpay, Saglam Suadiye, Neselioglu Salim, Erel Özcan, Acıpayam Can
Pediatric Gastroenterology, Kahramanmaras Sutcu Imam University Medical Faculty, Kahramanmaraş, TUR.
Biochemistry, İzmir Katip Çelebi University Atatürk Training and Research Hospital, Izmir, TUR.
Cureus. 2020 Dec 2;12(12):e11849. doi: 10.7759/cureus.11849.
Background and Aims Fatty liver increases oxidative stress and may trigger antioxidant mechanisms. We aimed to compare the levels of vitamin D, which has antioxidant properties, as well as total oxidant status (TOS), total antioxidant status (TAS), and catalase between patients with nonalcoholic fatty liver (NAFL) and the control group. Methods We compared vitamin D, TOS, TAS, catalase levels, and other biochemical parameters between pediatric patients with ultrasonographically detected NAFL and an age-matched healthy control group. Results NAFL patients had a significantly lower vitamin D level (p < 0.001). The patient group also had significantly greater height, weight, body mass index (BMI) Z score, parathyroid hormone, triglyceride, glucose, antioxidant (TAS and catalase), and TOS levels compared to the controls (p ≥ 0.001). There was no significant difference between the obese and non-obese NAFL patients with respect to TAS, TOS, catalase levels, and other biochemical parameters (p < 0.05). There was a positive correlation between height, weight, BMI Z score, and hepatosteatosis grade, and TAS, TOS, and catalase levels, and a negative correlation with vitamin D level. We also found a negative correlation between vitamin D level and TOS and catalase level. Conclusions Our study revealed lower levels of vitamin D and higher levels of oxidant-antioxidants including TOS, TAS, and catalase in patients with NAFL.
背景与目的 脂肪肝会增加氧化应激并可能触发抗氧化机制。我们旨在比较具有抗氧化特性的维生素D水平，以及非酒精性脂肪肝（NAFL）患者与对照组之间的总氧化状态（TOS）、总抗氧化状态（TAS）和过氧化氢酶水平。方法 我们比较了超声检查发现患有NAFL的儿科患者与年龄匹配的健康对照组之间的维生素D、TOS、TAS、过氧化氢酶水平及其他生化参数。结果 NAFL患者的维生素D水平显著更低（p < 0.001）。与对照组相比，患者组的身高、体重、体重指数（BMI）Z评分、甲状旁腺激素、甘油三酯、血糖、抗氧化剂（TAS和过氧化氢酶）及TOS水平也显著更高（p ≥ 0.001）。肥胖与非肥胖的NAFL患者在TAS、TOS、过氧化氢酶水平及其他生化参数方面无显著差异（p < 0.05）。身高、体重、BMI Z评分与肝脂肪变性分级以及TAS、TOS和过氧化氢酶水平呈正相关，与维生素D水平呈负相关。我们还发现维生素D水平与TOS和过氧化氢酶水平呈负相关。结论 我们的研究揭示了NAFL患者的维生素D水平较低，而包括TOS、TAS和过氧化氢酶在内的氧化-抗氧化剂水平较高。
