Lee Wee Chee, Mokhtar Siti Safiah, Munisamy Seetha, Yahaya Sahran, Rasool Aida Hanum Ghulam
Pharmacology Vascular Laboratory, School of Medical Sciences, Universiti Sains Malaysia (Health Campus), 16150 Kota Bharu, Kelantan, Malaysia.
Department of Orthopedics, School of Medical Sciences, Universiti Sains Malaysia (Health Campus), 16150 Kota Bharu, Kelantan, Malaysia.
Cell Mol Biol (Noisy-le-grand). 2018 May 30;64(7):60-69.
Diabetes mellitus is an epidemic that is gaining global concern. Chronic hyperglycemia in diabetes induces the excess production of free radicals. The deleterious effects of excess free radicals are encountered by endogenous antioxidant defense system. Imbalance between free radicals production and antioxidants defense mechanisms leads to a condition known as "oxidative stress". Diabetes mellitus is associated with augmented oxidative stress that induced micro- and macrovascular complications, which presents a significant risk for cardiovascular events. Low vitamin D levels in the body have also been reported to be associated with the pathogenesis of diabetes and enhanced oxidative stress. The article is to review available literature and summarize the relationship between oxidative stress and vitamin D levels in diabetes. We also review the effects of vitamin D analogs supplementation in improving oxidative stress in diabetics.
糖尿病是一种日益引起全球关注的流行病。糖尿病中的慢性高血糖会诱导自由基的过量产生。内源性抗氧化防御系统会应对过量自由基的有害影响。自由基产生与抗氧化防御机制之间的失衡会导致一种称为“氧化应激”的状况。糖尿病与氧化应激增加有关，氧化应激会诱发微血管和大血管并发症，这对心血管事件构成重大风险。据报道，体内维生素D水平低也与糖尿病的发病机制和氧化应激增强有关。本文旨在综述现有文献，总结糖尿病中氧化应激与维生素D水平之间的关系。我们还综述了补充维生素D类似物对改善糖尿病患者氧化应激的作用。
