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Complete Response to PD-1 Inhibition in an Adolescent With Relapsed Clear Cell Adenocarcinoma of the Cervix Predicted by Neoepitope Burden and APOBEC Signature.

作者信息

Levinson Anya, Lee Alex G, Martell Henry J, Breese Marcus R, Zaloudek Charles, Van Ziffle Jessica, Laguna Benjamin, Leung Stanley G, Chen M Dwight, Chen Lee-May, Pfeil Jacob, Ladwig Nicholas R, Shah Avanthi Tayi, Behroozfard Inge, Rao Arjun Arkal, Salama Sofie R, Sweet-Cordero E Alejandro, Stieglitz Elliot

机构信息

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.

出版信息

JCO Precis Oncol. 2020 Nov 2;4. doi: 10.1200/PO.20.00132. eCollection 2020.

DOI:10.1200/PO.20.00132
PMID:33283136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7713560/
Abstract
摘要

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Front Immunol. 2020 Nov 10;11:483296. doi: 10.3389/fimmu.2020.483296. eCollection 2020.
2
The repertoire of mutational signatures in human cancer.人类癌症中的突变特征谱。
Nature. 2020 Feb;578(7793):94-101. doi: 10.1038/s41586-020-1943-3. Epub 2020 Feb 5.
3
Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer types.
Cancer Med. 2023 Dec;12(23):21545-21560. doi: 10.1002/cam4.6711. Epub 2023 Nov 17.
4
Clear cell carcinoma of the uterine cervix; an unusual HPV-independent tumor: Clinicopathological features, PD-L1 expression, and mismatch repair protein deficiency status of 16 cases.子宫颈透明细胞癌；一种不常见的非HPV相关肿瘤：16例病例的临床病理特征、PD-L1表达及错配修复蛋白缺陷状态
Turk J Obstet Gynecol. 2023 Sep 4;20(3):164-173. doi: 10.4274/tjod.galenos.2023.62819.
5
Primary Clear Cell Adenocarcinoma of the Uterine Cervix in a 14-Year-Old Virgin Girl: Case Report.14 岁处女宫颈原发性透明细胞腺癌 1 例报告。
Int J Environ Res Public Health. 2022 Dec 11;19(24):16652. doi: 10.3390/ijerph192416652.
多癌种中 APOBEC 突变特征、APOBEC3 基因表达和种系缺失的综合基因组分析，以及免疫原性。
BMC Med Genomics. 2019 Sep 18;12(1):131. doi: 10.1186/s12920-019-0579-3.
4
Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial.尼伏鲁单抗单药治疗复发性或转移性宫颈癌、阴道癌或外阴癌的安全性和疗效：来自 I/II 期 CheckMate 358 试验的结果。
J Clin Oncol. 2019 Nov 1;37(31):2825-2834. doi: 10.1200/JCO.19.00739. Epub 2019 Sep 5.
5
Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer.核苷酸切除修复缺陷与癌症中观察到的突变特征有关。
Genome Res. 2019 Jul;29(7):1067-1077. doi: 10.1101/gr.246223.118. Epub 2019 Jun 20.
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-mutated clear cell cervical cancer associated with in-utero diethylstilbestrol exposure.与子宫内己烯雌酚暴露相关的突变型透明细胞宫颈癌。
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