Dept. of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, Greifswald, Germany.
Institute for Community Medicine, Div. SHIP - Clinical Epidemiological Research, University Medicine Greifswald, Greifswald, Germany.
Acta Paediatr. 2021 May;110(5):1452-1460. doi: 10.1111/apa.15701. Epub 2020 Dec 10.
The aim was to investigate socio-economic risk factors for maternal underweight before pregnancy and then associations of underweight with neonatal outcomes.
Data of 3401 mother-child dyads from the population-based birth cohort Survey of Neonates in Pomerania (SNiP) were analysed.
Bivariate analysis showed that underweighted mothers were younger, smoked more often, had a lower equivalent income and lower socio-economic status (employment status and/or educational level) compared to women with normal weight. The final prediction model revealed that only younger maternal age (OR = 0.93; 95%-CI = 0.90-0.97) and maternal smoking during pregnancy (OR = 2.52; 95%-CI = 1.74-3.66) were associated with underweight. Compared to women with normal pre-pregnancy BMI, underweight women had an increased chance of premature labour (OR = 1.73; 95% CI: 1.29-2.31) and a reduced placental weight. The offspring of underweight women had an increased risk of late preterm birth (OR = 1.82; 95% CI: 1.21-2.74) and birthweight < 2500 g (OR = 1.91; 95% CI: 1.23-2.95).
Smoking during pregnancy and a younger age were identified as risk factors for maternal pre-pregnancy underweight which then was associated with late preterm birth and low birthweight.
本研究旨在探讨妊娠前母体体重不足的社会经济风险因素，然后分析体重不足与新生儿结局的关系。
对基于人群的波美拉尼亚新生儿调查（SNiP）的 3401 对母婴对子数据进行了分析。
单变量分析显示，与体重正常的女性相比，体重不足的母亲年龄较小，吸烟更频繁，收入水平和社会经济地位（就业状况和/或教育程度）较低。最终的预测模型显示，只有母亲年龄较小（OR=0.93；95%CI=0.90-0.97）和孕期吸烟（OR=2.52；95%CI=1.74-3.66）与体重不足有关。与妊娠前 BMI 正常的女性相比，体重不足的女性早产（OR=1.73；95%CI：1.29-2.31）和胎盘重量减少的几率增加。体重不足的女性所生的婴儿晚期早产（OR=1.82；95%CI：1.21-2.74）和出生体重<2500 克（OR=1.91；95%CI：1.23-2.95）的风险增加。
孕期吸烟和年龄较小被确定为妊娠前母体体重不足的危险因素，而体重不足与晚期早产和低出生体重有关。
