Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, c/ Pedro Cerbuna 12, 50009, Zaragoza, Spain.
CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 28029, Madrid, Spain.
Angew Chem Int Ed Engl. 2021 Feb 15;60(7):3449-3453. doi: 10.1002/anie.202013563. Epub 2021 Jan 19.
The ring-opening polymerisation of α-amino acid N-carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted and narrow molecular weight distributions. Here we show how polyoxometalates (POMs)-redox-active molecular metal-oxide anions-can serve as inorganic scaffold initiators for such NCA polymerisations. This "On-POM polymerisation" strategy serves as an innovative platform to design hybrid materials with additive or synergistic properties stemming from the inorganic and polypeptide component parts. We have used this synthetic approach to synthesise a library of bactericidal poly(lysine)-POM hybrid derivatives that can be used to prevent biofilm formation. This versatile "On-POM polymerisation" method provides a flexible synthetic approach for combining inorganic scaffolds with amino acids, and the potential to tailor and improve the specificity and performance of hybrid antimicrobial materials.
α-氨基酸 N-羧酸酐（NCAs）的开环聚合为具有预测和窄分子量分布的多肽提供了一种简单且可扩展的方法。在这里，我们展示了多金属氧酸盐（POM）-氧化还原活性分子金属氧化物阴离子-如何作为此类 NCA 聚合的无机支架引发剂。这种“On-POM 聚合”策略是一种创新平台，可以设计具有源自无机和多肽成分的附加或协同特性的混合材料。我们已经使用这种合成方法合成了一系列具有杀菌作用的聚赖氨酸-POM 混合衍生物，可以用于防止生物膜形成。这种多功能的“On-POM 聚合”方法为将无机支架与氨基酸结合提供了一种灵活的合成方法，并且有可能调整和改善混合抗菌材料的特异性和性能。
