黑色素瘤的形成：黑色素瘤起始的分子和细胞变化
Making a melanoma: Molecular and cellular changes underlying melanoma initiation.
作者信息
Darp Revati, Ceol Craig
机构信息
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Department of Molecular, Cellular and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.
出版信息
Pigment Cell Melanoma Res. 2021 Mar;34(2):280-287. doi: 10.1111/pcmr.12950. Epub 2021 Jan 8.
PMID:33283422
Abstract
Melanoma arises from the melanocyte lineage and is the most aggressive and lethal form of skin cancer. There are several genetic, genomic, and cellular changes associated with melanoma initiation. Here, we discuss these alterations and the melanoma cells of origin in which they are proposed to promote melanomagenesis.
摘要
黑色素瘤起源于黑素细胞谱系，是皮肤癌中最具侵袭性和致命性的形式。有几种与黑色素瘤起始相关的基因、基因组和细胞变化。在这里，我们讨论这些改变以及据认为它们促进黑色素瘤发生的黑色素瘤起源细胞。
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