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探索诱导多能干细胞在癌症研究和治疗中的广阔前景。

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy.

机构信息

Novin Genome (NG) Lab, Research and Development Center for Biotechnology, Shahrekord, Iran.

Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

出版信息

Mol Cancer. 2023 Nov 28;22(1):189. doi: 10.1186/s12943-023-01873-0.

Abstract

The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. The formation of cancer is a multifaceted process influenced by genetic, epigenetic, and environmental factors. iPSCs offer a distinctive platform for investigating the origin of cancer, paving the way for novel approaches to cancer treatment, drug testing, and tailored medical interventions. This review article will provide an overview of the science behind iPSCs, the current limitations and challenges in iPSC-based cancer therapy, the ethical and social implications, and the comparative analysis with other stem cell types for cancer treatment. The article will also discuss the applications of iPSCs in tumorigenesis, the future of iPSCs in tumorigenesis research, and highlight successful case studies utilizing iPSCs in tumorigenesis research. The conclusion will summarize the advancements made in iPSC-based tumorigenesis research and the importance of continued investment in iPSC research to unlock the full potential of these cells.

摘要

iPS 细胞的出现给干细胞研究带来了重大变革,为癌症治疗的发展开辟了广阔的途径。癌症的形成是一个受遗传、表观遗传和环境因素影响的多方面过程。iPS 细胞为研究癌症的起源提供了一个独特的平台,为癌症治疗、药物测试和个性化医疗干预开辟了新的途径。这篇综述文章将概述 iPS 细胞背后的科学原理、基于 iPS 细胞的癌症治疗目前的局限性和挑战、伦理和社会影响,以及与其他类型的干细胞在癌症治疗方面的比较分析。文章还将讨论 iPS 细胞在肿瘤发生中的应用、iPS 细胞在肿瘤发生研究中的未来前景,并强调利用 iPS 细胞进行肿瘤发生研究的成功案例。结论将总结基于 iPS 细胞的肿瘤发生研究的进展,以及持续投资 iPS 细胞研究以释放这些细胞的全部潜力的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cef/10683363/15c80a9fa7f7/12943_2023_1873_Fig1_HTML.jpg

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