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[乳胶聚合稳定剂在各种测试系统中的诱变作用]

[Mutagenic action of latex polymerization stabilizers in various test systems].

作者信息

Arutiunian R M, Zalinian G G, Mugnetsian E G, Gukasian L A

出版信息

Tsitol Genet. 1987 Nov-Dec;21(6):450-4.

PMID:3328352
Abstract

The cytogenetic activity of latex polymerization stabilizers (monoethanolamine, triethanolamine and neozon-D) is investigated in three different test systems. It is shown that monoethanolamine and triethanolamine are weak inductors of chromosome breaks in the culture of human lymphocytes and in the Crepis capillaris seeds and induce low levels of gene mutations in the Ames systems. The third stabilizer--neozon-D manifests higher mutagenic activity and definite cytotoxic effect. Monoethanolamine and triethanolamine as to their weak mutagenic effect are recommended as preferable stabilizers to be used in the latex industry.

摘要

在三种不同的测试系统中研究了乳胶聚合稳定剂(单乙醇胺、三乙醇胺和新诺宗-D)的细胞遗传学活性。结果表明,单乙醇胺和三乙醇胺在人类淋巴细胞培养物和碎米荠种子中是染色体断裂的弱诱导剂,并且在艾姆斯试验系统中诱导低水平的基因突变。第三种稳定剂——新诺宗-D表现出更高的诱变活性和一定的细胞毒性作用。鉴于单乙醇胺和三乙醇胺的诱变作用较弱,推荐将其作为乳胶工业中更适宜使用的稳定剂。

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