Riederer Monika, Wallner Marlies, Schweighofer Natascha, Fuchs-Neuhold Bianca, Rath Anna, Berghold Andrea, Eberhard Katharina, Groselj-Strele Andrea, Staubmann Wolfgang, Peterseil Marie, Waldner Irmgard, Mayr Johannes A, Rothe Michael, Holasek Sandra, Maunz Susanne, Pail Elisabeth, van der Kleyn Moenie
Institute of Biomedical Science, University of Applied Sciences JOANNEUM, Graz, Austria.
Institute of Dietetics and Nutrition, Health Perception Lab, University of Applied Sciences JOANNEUM, Graz, Austria.
Arch Physiol Biochem. 2023 Jun;129(3):563-574. doi: 10.1080/13813455.2020.1846204. Epub 2020 Dec 7.
Interested in maternal determinants of infant fat mass index (FMI) and fat-free mass index (FFMI), considered as predictors for later development of obesity, we analysed amino acids (AA) and oxylipins in maternal serum and breast milk (BM). FMI and FFMI were calculated in 47 term infants aged 4 months (T4). Serum AA were analysed in pregnancy (T1, T2) and 6-8 weeks postpartum (T3). At T3, AA and oxylipins were analysed in BM. Biomarker-index-associations were identified by regression analysis. Infant FMI (4.1 ± 1.31 kg/m; MW ± SD) was predicted by T2 proline ( adj.: 7.6%, = .036) and T3 BM 11-hydroxy-eicosatetraenoic-acid (11-HETE) and 13-hydroxy-docosahexaenoic-acid (13-HDHA; together:35.5% adj., < .001). Maternal peripartum antibiotics (AB) emerged as confounders (+AB: 23.5% higher FMI; = .025). Infant FFMI (12.1 ± 1.19 kg/m; MW ± SD) was predicted by histidine ( adj.: 14.5%, < .001) and 17-HDHA (BM, adj.:19.3%, < .001), determined at T3. Confirmed in a larger cohort, the parameters could elucidate connections between maternal metabolic status, nutrition, and infant body development.
我们对婴儿脂肪量指数（FMI）和去脂体重指数（FFMI）的母体决定因素感兴趣，这两个指数被视为肥胖症后期发展的预测指标，我们分析了母体血清和母乳（BM）中的氨基酸（AA）和氧化脂质。对47名4个月大的足月儿（T4）计算了FMI和FFMI。在孕期（T1、T2）和产后6 - 8周（T3）分析血清AA。在T3时，分析了母乳中的AA和氧化脂质。通过回归分析确定生物标志物 - 指数关联。婴儿FMI（4.1±1.31kg/m；均数±标准差）由T2脯氨酸预测（校正：7.6%，P = 0.036）以及T3母乳中的11 - 羟基 - 二十碳四烯酸（11 - HETE）和13 - 羟基 - 二十二碳六烯酸（13 - HDHA；合计：校正后35.5%，P < 0.001）。母体围产期抗生素（AB）成为混杂因素（使用AB：FMI高23.5%；P = 0.025）。婴儿FFMI（12.1±1.19kg/m；均数±标准差）由组氨酸预测（校正：14.5%，P < 0.001）以及在T3时测定的17 - HDHA（母乳，校正：19.3%，P < 0.001）。在更大的队列中得到证实后，这些参数可以阐明母体代谢状态、营养与婴儿身体发育之间的联系。
