Ondokuz Mayis University, Faculty of Medicine, Department of Internal Medicine, Samsun, Turkey.
Amasya University, Faculty of Medicine, Department of Infection Disease, Amasya, Turkey.
Biomarkers. 2021 Mar;26(2):114-118. doi: 10.1080/1354750X.2020.1861099. Epub 2021 Jan 13.
Coronavirus disease-2019 (COVID-19) with lung involvement frequently causes morbidity and mortality. Advanced age appears to be the most important risk factor. The receptor for advanced glycation end-product (RAGE) pathway is considered to play important roles in the physiological aging and pathogenesis of lung diseases. This study aimed to investigate the possible relationship between COVID-19 and RAGE pathway.
This study included 23 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed tomography. Serum soluble-RAGE (sRAGE) levels were determined using enzyme-linked immunosorbent assay.
The sRAGE levels were significantly higher in the asymptomatic group than in the control group. Age, fibrinogen, C-reactive protein, and ferritin levels were higher and the sRAGE level was lower in the patients with lung involvement than in the asymptomatic patients.
In this study, patients with high sRAGE levels were younger and had asymptomatic COVID-19. Patients with low sRAGE levels were elderly patients with lung involvement, which indicates that the RAGE pathway plays an important role in the aggravation of COVID-19.
新冠肺炎（COVID-19）常导致肺部受累，引起发病率和死亡率。高龄似乎是最重要的危险因素。晚期糖基化终产物（RAGE）途径受体被认为在肺部疾病的生理衰老和发病机制中发挥重要作用。本研究旨在探讨 COVID-19 与 RAGE 途径之间的可能关系。
本研究纳入了 23 例无症状患者和 35 例肺部受累的 COVID-19 患者，以及 22 名健康志愿者。通过计算机断层扫描确定肺部受累情况。采用酶联免疫吸附试验测定血清可溶性 RAGE（sRAGE）水平。
无症状组的 sRAGE 水平明显高于对照组。与无症状患者相比，肺部受累患者的年龄、纤维蛋白原、C 反应蛋白和铁蛋白水平较高，sRAGE 水平较低。
在本研究中，高 sRAGE 水平的患者年龄较小且患有无症状 COVID-19。低 sRAGE 水平的患者为老年肺部受累患者，这表明 RAGE 途径在 COVID-19 的加重中起重要作用。
