Skinner Owen T, Souza Carlos H de M, Kim Dae Young
Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri.
Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida.
Vet Surg. 2021 Jan;50(1):150-157. doi: 10.1111/vsu.13549. Epub 2020 Dec 7.
To determine the rate of nodal metastasis to the medial retropharyngeal (MRP) and deep cervical lymph nodes in dogs surgically treated for thyroid carcinoma.
Retrospective study.
Twenty-two client-owned dogs.
Medical records between July 2015 and October 2019 at the Universities of Missouri and Florida were reviewed. Dogs that underwent thyroidectomy with concurrent elective MRP lymphadenectomy ± deep cervical lymphadenectomy were included. Tumor site, preoperative staging, and histopathological findings were recorded.
Twenty-two dogs with 26 total thyroid carcinomas were included. Primary tumors were lateralized in 19 dogs, bilateral in two dogs, and bilateral and midline ectopic in one dog. All dogs underwent ipsilateral MRP resection, including bilateral resection in dogs with bilateral tumors. Three contralateral MRP lymph nodes were excised from dogs with unilateral carcinomas. Four deep cervical lymph nodes and one superficial cervical lymph node were excised. Metastases were identified in 14 lymph nodes in 10 of 22 (45%) dogs. All four excised deep cervical lymph nodes and one contralateral MRP lymph node were identified as metastatic. Size of deposit could be classified in 13 of 14 metastatic lymph nodes. Macrometastasis was detected in seven lymph nodes, micrometastasis was detected in one node, and isolated tumor cells were detected in five lymph nodes.
Regional metastasis was common within the lymph nodes sampled in this population of dogs with thyroid carcinoma.
These results provide evidence to justify further exploration of a larger population to verify the rate of regional metastasis and determine the prognostic impact of nodal metastasis.
确定接受甲状腺癌手术治疗的犬咽后内侧（MRP）淋巴结和颈深淋巴结的转移率。
回顾性研究。
22只客户拥有的犬。
回顾了2015年7月至2019年10月密苏里大学和佛罗里达大学的病历。纳入接受甲状腺切除术并同期选择性MRP淋巴结清扫术±颈深淋巴结清扫术的犬。记录肿瘤部位、术前分期和组织病理学结果。
纳入22只患26个甲状腺癌的犬。19只犬的原发性肿瘤位于一侧，2只犬为双侧，1只犬为双侧且中线异位。所有犬均接受同侧MRP切除，双侧肿瘤的犬进行双侧切除。对单侧癌犬切除了3个对侧MRP淋巴结。切除了4个颈深淋巴结和1个颈浅淋巴结。22只犬中有10只（45%）的14个淋巴结发现转移。所有切除的4个颈深淋巴结和1个对侧MRP淋巴结均被确定为转移。14个转移淋巴结中有13个可对转移灶大小进行分类。7个淋巴结检测到巨转移，1个淋巴结检测到微转移，5个淋巴结检测到孤立肿瘤细胞。
在这群患有甲状腺癌的犬所采集的淋巴结中，区域转移很常见。
这些结果为进一步研究更大的群体以验证区域转移率并确定淋巴结转移的预后影响提供了证据。
