Puciłowski O
Acta Neurobiol Exp (Wars). 1987;47(5-6):213-38.
The aim of the present study is to present the experimental evidence, mainly that collected over recent years by the author, in support of the involvement of the dopaminergic mesolimbic system in the mechanism of affective aggression in the rat and its interactions with other monoaminergic systems. Dopamine has been found to play an important facilitatory role in affective aggression, accomplished, at least in its essential part by the mesolimbic A10 neurons projecting into the nucleus accumbens septi (NAS). Norepinephrine inhibits this behavior, the effect being mediated by the locus coeruleus ascending neurons reaching NAS and the amygdala (AMY), and involving activation of alpha 1 adrenoceptors. Also serotonergic effects on affective aggression are of inhibitory nature. They are conveyed by the neurons of the dorsal raphe, but not of the median raphe, projecting into the AMY. The NAS does not play any important part in the serotonergic control of aggression. There appears to exist a reciprocal interaction between these three monoaminergic systems in respect to their modulatory function in affective aggression. The significance of these findings for diagnosis, treatment and prevention of violent behavior in the clinic is discussed.
本研究的目的是提供实验证据，主要是作者近年来收集的证据，以支持多巴胺能中脑边缘系统参与大鼠情感攻击机制及其与其他单胺能系统的相互作用。已发现多巴胺在情感攻击中起重要的促进作用，至少在其主要部分是由投射到伏隔核（NAS）的中脑边缘A10神经元完成的。去甲肾上腺素抑制这种行为，其作用是由到达NAS和杏仁核（AMY）的蓝斑上行神经元介导的，并且涉及α1肾上腺素能受体的激活。5-羟色胺对情感攻击的影响也是抑制性的。它们由投射到AMY的背侧中缝核神经元传递，但不由中缝正中核神经元传递。NAS在5-羟色胺对攻击行为的控制中不发挥任何重要作用。在情感攻击的调节功能方面，这三种单胺能系统之间似乎存在相互作用。讨论了这些发现对临床暴力行为的诊断、治疗和预防的意义。
