Role of basement membranes in cell differentiation.

Extracellular matrices have diverse biological effects, including promoting the growth and differentiation of various cells of epithelial origin. The components of one of these matrices, the basement membrane, are discussed, as well as studies using these components alone or in combination with cells in culture. The particular response observed varies with the cell type examined and appears to be dependent on multiple interactions with components of the matrix. Potential uses for a basement membrane-derived matrix in vitro and in vivo are being developed.