Alzheimer's disease and other cognitive disorders Unit, Neurology Service, Hospital Clinic, Barcelona, Spain.
Institut d'Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain.
J Alzheimers Dis. 2021;79(1):415-422. doi: 10.3233/JAD-200904.
The semantic variant of primary progressive aphasia (svPPA) is characterized by a progressive loss of semantic knowledge impairing the ability to name and to recognize the meaning of words.
We aimed to evaluate the immediate and short-term effect of errorless learning speech therapy on the naming and recognition of commonly used words in patients with svPPA.
Eight participants diagnosed with svPPA received 16 sessions of intensive errorless learning speech therapy. Naming and word comprehension tasks were evaluated at baseline, immediately postintervention, and at follow-up after 1, 3, and 6 months. These evaluations were performed using two item sets (a trained list and an untrained list).
In the naming tasks, patients showed a significant improvement in trained items immediately after the intervention, but that improvement decayed progressively when therapy ended. No improvements were found either in trained comprehension or in untrained tasks.
Errorless learning therapy could improve naming ability in patients with svPPA. This effect may be due to the relative preservation of episodic memory, but the benefit is not maintained over time, presumably because there is no consolidation.
原发性进行性失语症（svPPA）的语义变体的特征是语义知识进行性丧失，损害了命名和识别单词含义的能力。
我们旨在评估无错误学习言语治疗对 svPPA 患者常用词命名和识别的即时和短期效果。
8 名被诊断患有 svPPA 的参与者接受了 16 次强化无错误学习言语治疗。在基线、干预后即刻以及 1、3 和 6 个月后的随访中，使用两个项目集（训练列表和未训练列表）评估命名和单词理解任务。
在命名任务中，患者在干预后即刻显示出对训练项目的显著改善，但随着治疗结束，这种改善逐渐消退。在训练理解或未训练任务中均未发现改善。
无错误学习疗法可以改善 svPPA 患者的命名能力。这种效果可能是由于情景记忆的相对保留，但随着时间的推移，这种益处并没有得到维持，大概是因为没有巩固。
