Saadeldin Islam M, Khalil Wael A, Alharbi Mona G, Lee Seok Hee
Department of Animal Production, College of Food and Agricultural Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Department of Comparative Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia.
Animals (Basel). 2020 Dec 3;10(12):2281. doi: 10.3390/ani10122281.
Cryopreservation is an essential tool to preserve sperm cells for zootechnical management and artificial insemination purposes. Cryopreservation is associated with sperm damage via different levels of plasma membrane injury and oxidative stress. Nanoparticles are often used to defend against free radicals and oxidative stress generated through the entire process of cryopreservation. Recently, artificial or natural nanovesicles including liposomes and exosomes, respectively, have shown regenerative capabilities to repair damaged sperm during the freeze-thaw process. Exosomes possess a potential pleiotropic effect because they contain antioxidants, lipids, and other bioactive molecules regulating and repairing spermatozoa. In this review, we highlight the current strategies of using nanoparticles and nanovesicles (liposomes and exosomes) to combat the cryoinjuries associated with semen cryopreservation.
冷冻保存是用于畜牧管理和人工授精目的而保存精子细胞的一项重要工具。冷冻保存与通过不同程度的质膜损伤和氧化应激造成的精子损伤有关。纳米颗粒常被用于抵御冷冻保存全过程中产生的自由基和氧化应激。近来，分别包括脂质体和外泌体在内的人工或天然纳米囊泡已显示出在冻融过程中修复受损精子的再生能力。外泌体具有潜在的多效性作用，因为它们含有抗氧化剂、脂质及其他调节和修复精子的生物活性分子。在本综述中，我们重点介绍了目前使用纳米颗粒和纳米囊泡（脂质体和外泌体）来对抗与精液冷冻保存相关的冷冻损伤的策略。
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