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丘脑枕核单侧梗死后严重嗜睡- 1 例报告。

Severe hypersomnia after unilateral infarction in the pulvinar nucleus- a case report.

机构信息

Department of Neurology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark.

Department of Neurophysiology, Odense University Hospital, Odense, Denmark.

出版信息

BMC Neurol. 2020 Dec 7;20(1):442. doi: 10.1186/s12883-020-02018-2.

DOI:10.1186/s12883-020-02018-2
PMID:33287737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7720584/
Abstract

BACKGROUND

Although a central role of the thalamus for sleep regulation is undisputed, the exact localization of the crucial structures within the thalamus remains controversial.

CASE PRESENTATION

Here we report a 35 year old woman with no prior comorbidities who developed severe and persistent hypersomnia with long sleep time after a small right-sided MRI-verified thalamic stroke affecting the dorsal part of the pulvinar and the dorsolateral boarders of the dorsomedial nuclei.

CONCLUSION

The observed symptoms suggest a crucial role of posterior thalamus but not the midline parts of the thalamus in sleep-wake control.

摘要

背景

尽管丘脑在睡眠调节中的核心作用是毋庸置疑的，但丘脑内关键结构的确切位置仍存在争议。

病例介绍

本文报告了一例 35 岁女性，无既往合并症，在 MRI 证实右侧丘脑小卒中后出现严重且持续的嗜睡，总睡眠时间延长，病灶累及后丘脑被盖部和背内侧核的背外侧边界。

结论

观察到的症状表明，后丘脑而非丘脑中线部位在后睡眠-觉醒控制中起关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/274e/7720584/6ee5f73c5b1a/12883_2020_2018_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/274e/7720584/6ee5f73c5b1a/12883_2020_2018_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/274e/7720584/6ee5f73c5b1a/12883_2020_2018_Fig1_HTML.jpg

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Neurobiol Sleep Circadian Rhythms. 2018 Mar 1;5:68-77. doi: 10.1016/j.nbscr.2018.02.003. eCollection 2018 Jun.
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In-vivo probabilistic atlas of human thalamic nuclei based on diffusion- weighted magnetic resonance imaging.基于弥散加权磁共振成像的人脑丘脑核团的体内概率图谱。
Sci Data. 2018 Nov 27;5:180270. doi: 10.1038/sdata.2018.270.
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Mononucleosis: A Possible Cause of Idiopathic Hypersomnia.
传染性单核细胞增多症：特发性嗜睡症的一个可能病因。
Front Neurol. 2018 Oct 31;9:922. doi: 10.3389/fneur.2018.00922. eCollection 2018.
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Sleep-wake control and the thalamus.睡眠-觉醒控制与丘脑。
Curr Opin Neurobiol. 2018 Oct;52:188-197. doi: 10.1016/j.conb.2018.08.002. Epub 2018 Aug 23.
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Limbic circuitry of the midline thalamus.中线丘脑的边缘环路
Neurosci Biobehav Rev. 2015 Jul;54:89-107. doi: 10.1016/j.neubiorev.2015.01.014. Epub 2015 Jan 20.
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Control of sleep and wakefulness.睡眠和觉醒的控制。
Physiol Rev. 2012 Jul;92(3):1087-187. doi: 10.1152/physrev.00032.2011.
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The sleep relay--the role of the thalamus in central and decentral sleep regulation.睡眠中继——丘脑在中枢和外周睡眠调节中的作用。
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