USERN Office, Abadan Faculty of Medical Sciences, Abadan, Iran.
BMC Res Notes. 2020 Dec 7;13(1):551. doi: 10.1186/s13104-020-05396-5.
In this study, the seroprevalence of anti-Toxoplasma gondii (T. gondii) specific antibodies in patients undergoing hemodialysis compared to the control group were evaluated. In this case-control study, 200 hemodialysis patients (HDP) and 100 healthy controls were participated. The specific antibodies (IgG/IgM) in both groups were tested using enzyme-linked immunosorbent assay (ELISA) method. A structured questionnaire containing some demographic information was completed for each person in case and control groups.
The overall seroprevalence of T. gondii infection was 49.5% (99/200) and 23.0% (23/100) in the case and control groups, respectively. There was a significant association between seroprevalence of T. gondii infection and contact with cats (P < 0.001), consumption of raw/undercooked meat (P = 0.01), and source of drinking water (P = 0.001) in the hemodialysis patients. Also, in the control subjects, there were a significant association between consumption of raw/undercooked meat (P = 0.04) and source of drinking water (P = 0.001) with T. gondii infection. The findings showed a high seroprevalence of T. gondii infection in HDP compared with healthy controls; thus, we recommend the regular screening programs for T. gondii infection in this susceptible group.
本研究评估了与对照组相比，接受血液透析的患者抗弓形虫（T. gondii）特异性抗体的血清阳性率。在这项病例对照研究中，共纳入了 200 名血液透析患者（HDP）和 100 名健康对照者。使用酶联免疫吸附试验（ELISA）方法检测两组的特异性抗体（IgG/IgM）。为病例组和对照组的每个人填写了一份包含一些人口统计学信息的结构化问卷。
弓形虫感染的总血清阳性率分别为病例组的 49.5%（99/200）和对照组的 23.0%（23/100）。在血液透析患者中，弓形虫感染的血清阳性率与接触猫（P<0.001）、食用生/未煮熟的肉（P=0.01）和饮用水源（P=0.001）之间存在显著关联。此外，在对照组中，食用生/未煮熟的肉（P=0.04）和饮用水源（P=0.001）与弓形虫感染之间也存在显著关联。研究结果表明，HDP 中弓形虫感染的血清阳性率明显高于健康对照组；因此，我们建议对这个易感人群定期进行弓形虫感染筛查。
