IRCCS Istituto Ortopedico Rizzoli, SC Scienze e Tecnologie Chirurgiche - SS Piattaforma Scienze Omiche per Ortopedia Personalizzata, Bologna, Italy.
University of Palermo, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Section of Cellular Biology, Palermo, Italy.
Trends Endocrinol Metab. 2021 Feb;32(2):76-94. doi: 10.1016/j.tem.2020.11.007. Epub 2020 Dec 4.
Imbalance of bone homeostasis, with excessive bone resorption compared with bone formation, leads to the development of progressive osteopenia leading to lower bone resistance to load, with consequent pain and functional limitations. Phytochemicals with therapeutic and preventive effects against bone resorption have recently received increasing attention since they are potentially more suitable for long-term use than traditional therapeutic chemical compounds. In this systematic review of the literature of the past 5 years, comprehensive information is provided on flavonoids with potential antiresorption and pro-osteogenic effects. It aims to highlight the molecular mechanisms of these molecules, often epigenetic, and their possible pharmacological use, which is of great importance for the prevention and treatment of osteoporosis (OP).
骨稳态失衡，破骨作用强于成骨作用，导致进行性骨质疏松症的发生，使骨对负荷的抵抗力降低，从而引起疼痛和功能受限。具有抗吸收作用的植物化学物质具有治疗和预防作用，最近受到越来越多的关注，因为它们比传统的治疗性化合物更适合长期使用。在对过去 5 年文献的系统综述中，提供了具有潜在抗吸收和促成骨作用的类黄酮的综合信息。其目的是强调这些分子的分子机制，通常是表观遗传机制，以及它们可能的药理学用途，这对于骨质疏松症（OP）的预防和治疗非常重要。
