Singh Sumit Randhir, Iovino Claudio, Zur Dinah, Masarwa Dua, Iglicki Matias, Gujar Ramkailash, Lupidi Marco, Maltsev Dmitrii S, Bousquet Elodie, Bencheqroun Mehdi, Amoroso Francesca, Lima Luiz H, Padhy Srikanta Kumar, Govindahari Vishal, Chandra Khushboo, Souied Eric H, Rodriguez Francisco J, Daza Laura A, Rios Hernan A, Cagini Carlo, Peiretti Enrico, Behar-Cohen Francine, Chhablani Jay
Jacobs Retina Center, University of California San Diego, La Jolla, California, USA.
Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Università degli studi della Campania "Luigi Vanvitelli", Naples, Italy.
Br J Ophthalmol. 2022 Apr;106(4):553-558. doi: 10.1136/bjophthalmol-2020-317422. Epub 2020 Dec 7.
To identify the factors predicting the visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR) through 12 months.
Patients with diagnosis of CSCR, either acute or chronic, were included in this multicentric, retrospective study. Demographic factors; systemic risk factors; central macular thickness (CMT), subfoveal choroidal thickness (SFCT), linear extent of ellipsoid zone (EZ) and interdigitation zone damage on optical coherence tomography; details of leak on fluorescein angiography and indocyanine green angiography were included as predictors of anatomical and visual outcomes. Regression analysis was performed to correlate the changes in best corrected visual acuity (BCVA) and resolution of disease activity.
A total of 231 eyes of 201 patients with a mean age (49.7±11.8 years) were analysed. A total of 97 and 134 eyes were classified as acute and chronic CSCR. BCVA (0.35±0.31 to 0.24±0.34; p<0.001), baseline optical coherence tomography (OCT) parameters including CMT (p<0.001), subretinal fluid (SRF) height (p<0.001) and SFCT (p=0.05) showed a significant change through 12 months. Multivariate regression analysis showed change in CMT (p≤0.01) and SRF height at baseline (p=0.05) as factors predictive of good visual outcome. Logistic regression analysis revealed changes in both CMT (p=0.009) and SFCT (p=0.01) through 12 months to correlate with the resolution of disease.
OCT parameters such as changes in both CMT and SFCT along with subfoveal EZ damage can be predictive of disease resolution whereas changes in CMT and baseline SRF height correlate well with changes in BCVA through 12 months.
确定预测中心性浆液性脉络膜视网膜病变（CSCR）患者12个月时视力及解剖学转归的因素。
本多中心回顾性研究纳入急性或慢性CSCR诊断患者。人口统计学因素、全身危险因素、光学相干断层扫描（OCT）测量的中心黄斑厚度（CMT）、黄斑中心凹下脉络膜厚度（SFCT）、椭圆体带（EZ）线性范围及指状交叉区损伤；荧光素血管造影和吲哚菁绿血管造影渗漏细节作为解剖学和视力转归的预测指标。进行回归分析以关联最佳矫正视力（BCVA）变化和疾病活动度消退情况。
共分析201例患者的231只眼，平均年龄（49.7±11.8岁）。97只眼和134只眼分别分类为急性和慢性CSCR。BCVA（从0.35±0.31至0.24±0.34；p<0.001）、包括CMT（p<0.001）、视网膜下液（SRF）高度（p<0.001）和SFCT（p=0.05）在内的基线OCT参数在12个月时显示出显著变化。多因素回归分析显示CMT变化（p≤0.01）和基线SRF高度（p=0.05）是良好视力转归的预测因素。逻辑回归分析显示12个月期间CMT（p=0.009）和SFCT（p=0.01）的变化与疾病消退相关。
OCT参数如CMT和SFCT变化以及黄斑中心凹下EZ损伤可预测疾病消退，而CMT变化和基线SRF高度与12个月期间BCVA变化密切相关。
