Ahn Seong Joon, Tai Vincent, Winter Katrina P, Sarin Neeru, Toth Cynthia A
Department of Ophthalmology, Duke University School of Medicine, Durham, NC, United States.
Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea.
Front Med (Lausanne). 2025 Aug 12;12:1581191. doi: 10.3389/fmed.2025.1581191. eCollection 2025.
Pigment epithelial detachment (PED) is well-documented in adult retinal diseases but is rarely reported in neonates. This case describes a preterm infant, born at 31 weeks, who developed PED with thickened choroid at term-equivalent age, detected using handheld OCT. The PED emerged at 39 weeks postmenstrual age, coinciding with inhaled steroid treatment for respiratory distress, and resolved by 41 weeks after steroid discontinuation without structural damage. The temporal relationship suggests an association between steroid use and PED with choroidal changes. This case highlights the value of OCT in detecting retinal and choroidal abnormalities in preterm infants and underscores the potential impact of systemic conditions and medications on the choroid.
色素上皮脱离（PED）在成人视网膜疾病中已有充分记录，但在新生儿中很少见。本病例描述了一名31周出生的早产儿，在足月等效年龄时出现PED并伴有脉络膜增厚，通过手持光学相干断层扫描（OCT）检测到。PED在孕龄39周时出现，与因呼吸窘迫接受吸入性类固醇治疗同时发生，在停用类固醇后41周时消退，未造成结构损伤。时间上的关联表明类固醇使用与伴有脉络膜改变的PED之间存在关联。本病例突出了OCT在检测早产儿视网膜和脉络膜异常方面的价值，并强调了全身状况和药物对脉络膜的潜在影响。
