Maltsev Dmitrii S, Kulikov Alexey N, Burnasheva Maria A, Chhablani Jay
Department of Ophthalmology, Military Medical Academy, 21 Botkinskaya Street, St. Petersburg 194044, Russia.
Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russia.
Ther Adv Ophthalmol. 2023 Mar 21;15:25158414231160689. doi: 10.1177/25158414231160689. eCollection 2023 Jan-Dec.
The photoreceptor outer segment (PROS) layer demonstrates focal thinning above the fluorescein leakage in acute central serous chorioretinopathy (CSC); however, the nature of this phenomenon is not known.
To study the relationship between the PROS layer and thickness of the outer retinal layers above the fluorescein leakage in newly diagnosed acute CSC.
Single-center retrospective study.
All participants received multimodal imaging, including fluorescein angiography and optical coherence tomography. Thickness of PROS, outer nuclear layer (ONL), and ONL-outer plexiform layer (OPL) complex was measured above the leakage and outside the leakage within the area of neurosensory detachment. The number of intraretinal hyperreflective foci of the outer retina was counted. The correlation between PROS thickness and ONL, OPL-ONL complex thickness, and the number of intraretinal hyperreflective foci was calculated.
Fifty eyes of 48 patients (38 males and 10 females, 43.8 ± 10.6 years) with a mean symptom duration of 1.4 ± 1.3 months were included. PROS thickness above the fluorescein leakage showed a statistically significant correlation with ONL thickness, OPL-ONL complex thickness, and the number of hyperreflective foci in the outer retina, 0.57, 0.60, and -0.46, respectively ( < 0.001). Measuring the extent of PROS thinning above the leakage in newly diagnosed CSC allowed to predict self-resolution of subretinal fluid. The greatest linear dimension of PROS thinning showed an area under the receiver operating curve (ROC) curve of 0.98. The cases without PROS thinning had the fastest resolution of subretinal fluid.
PROS thinning above the fluorescein leakage in acute CSC is associated with thinning of the outer retinal layers and reveals mild outer retinal atrophy. The absence of PROS thinning predicts faster resolution of CSC.
在急性中心性浆液性脉络膜视网膜病变（CSC）中，光感受器外段（PROS）层在荧光素渗漏上方显示出局灶性变薄；然而，这种现象的本质尚不清楚。
研究新诊断的急性CSC中PROS层与荧光素渗漏上方视网膜外层厚度之间的关系。
单中心回顾性研究。
所有参与者均接受了多模态成像，包括荧光素血管造影和光学相干断层扫描。在神经感觉脱离区域内的渗漏上方和渗漏外测量PROS、外核层（ONL）以及ONL-外丛状层（OPL）复合体的厚度。计数视网膜外层视网膜内高反射灶的数量。计算PROS厚度与ONL、OPL-ONL复合体厚度以及视网膜内高反射灶数量之间的相关性。
纳入48例患者的50只眼（男性38例，女性10例，平均年龄43.8±10.6岁），平均症状持续时间为1.4±1.3个月。荧光素渗漏上方的PROS厚度与ONL厚度、OPL-ONL复合体厚度以及视网膜外层高反射灶数量分别呈显著统计学相关性，相关系数分别为0.57、0.60和-0.46（P<0.001）。测量新诊断的CSC中渗漏上方PROS变薄的程度可预测视网膜下液的自行消退。PROS变薄的最大线性尺寸显示受试者工作曲线（ROC）下面积为0.98。无PROS变薄的病例视网膜下液消退最快。
急性CSC中荧光素渗漏上方的PROS变薄与视网膜外层变薄相关，并显示出轻度视网膜外层萎缩。无PROS变薄预示着CSC消退更快。
