Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Sci Rep. 2020 Dec 7;10(1):21383. doi: 10.1038/s41598-020-78227-z.
The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of glycosylated hemoglobin (HbA1c) in non-diabetic humans with obesity. 5-HTT availability was measured by using positron emission tomography (PET) imaging with the 5-HTT selective radiotracer [C]DASB in 23 non-diabetic individuals with obesity and 14 healthy, non-obesity controls. Parametric images of binding potential BP were generated from the PET data and analyzed together with HbA1c levels by using volume of interest analysis for brain areas relevant to appetite control. Voxel-based morphometry (VBM) of individual magnetic resonance imaging data was further performed to correlate grey matter density (GMD) maps with HbA1c. We found significant negative correlations between HbA1c levels and BP in right and left hippocampus in obesity (r = - 0.717, p < 0.001, and r = - 0.557, p = 0.006, respectively). VBM analyses revealed that higher HbA1c levels were associated with GMD in the right para-hippocampal area. Our results indicate that chronically high blood glucose levels may evoke changes in hippocampal 5-HTT levels that are in part tied to local microstructure.
本研究旨在探究肥胖的非糖尿病个体体内中枢 5-羟色胺再摄取转运体（5-HTT）的可用性是否与血浆糖化血红蛋白（HbA1c）水平相关。通过使用 5-HTT 选择性放射性示踪剂 [C]DASB 结合正电子发射断层扫描（PET）成像，对 23 名肥胖的非糖尿病个体和 14 名健康的非肥胖对照者进行了 5-HTT 可用性的测量。从 PET 数据生成了结合势 BP 的参数图像，并通过对与食欲控制相关的脑区的感兴趣体积分析，将 BP 与 HbA1c 水平进行了联合分析。进一步对个体磁共振成像数据进行基于体素的形态学（VBM）分析，以将灰质密度（GMD）图谱与 HbA1c 进行关联。我们发现肥胖个体的右侧和左侧海马体中 HbA1c 水平与 BP 之间存在显著负相关（r= - 0.717，p < 0.001，和 r= - 0.557，p = 0.006）。VBM 分析显示，较高的 HbA1c 水平与右侧海马旁区的 GMD 相关。我们的结果表明，长期高血糖水平可能会引起海马体 5-HTT 水平的变化，而这种变化在一定程度上与局部微观结构有关。
