前列腺素 E 与 E2 引产的效果比较。
Labor induction with prostaglandin E versus E: a comparison of outcomes.
机构信息
Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
出版信息
J Perinatol. 2021 Apr;41(4):726-735. doi: 10.1038/s41372-020-00888-5. Epub 2020 Dec 7.
OBJECTIVE
To compare the peripartum outcomes when labor is induced with prostaglandins E versus E.
METHODOLOGY
The Consortium of Safe Labor database was utilized. Women with non-anomalous singletons >24 weeks gestation undergoing induction were analyzed. The primary endpoint was a composite adverse maternal outcome with a composite adverse neonatal outcome as our secondary outcome.
RESULTS
Of the 228,438 births within the database, 8229 (10.8%) met inclusion criteria with 4703 (55.7%) receiving PGE, and 3741 (44.3%), PGE. The rate of vaginal delivery was similar between both. Composite adverse maternal outcome, was more likely among the prostaglandin E: 7.2% vs. 1.5% (aOR 4.20; 95% CI 3.02-5.85); similar trend observed with composite adverse neonatal outcome rates: 4.6% vs. 1.4% (aOR 1.69; 95% CI 1.14-2.50).
CONCLUSION
Utilization of prostaglandin E, compared to E was associated with an increased likelihood of adverse maternal and neonatal outcomes.
目的
比较前列腺素 E 与 E 在引产时的围产期结局。
方法
利用安全分娩联合会数据库。对 24 周以上非畸形单胎孕妇进行引产分析。主要终点是复合不良母体结局，次要终点是复合不良新生儿结局。
结果
在数据库中的 228438 例分娩中，8229 例（10.8%）符合纳入标准，其中 4703 例（55.7%）接受 PGE，3741 例（44.3%）接受 PGE。两者的阴道分娩率相似。前列腺素 E 组的复合不良母体结局发生率更高，为 7.2% vs. 1.5%（aOR 4.20；95%CI 3.02-5.85）；复合不良新生儿结局发生率也有类似趋势，为 4.6% vs. 1.4%（aOR 1.69；95%CI 1.14-2.50）。
结论
与 E 相比，前列腺素 E 的使用与不良母婴结局的发生几率增加相关。
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