Amirchaghmaghi Maryam, Mahoozi Roya, Dalirsani Zohreh, Mostaan Leila Vazifeh, Hashemy Seyed Isaac, Shakeri Mohammad Taghi
Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
General Dentist, Mashhad, Iran.
Clin Exp Dent Res. 2020 Dec 1;7(4):574-80. doi: 10.1002/cre2.364.
Oral lichen planus (OLP) is a chronic mucocutaneous inflammatory disease, which is considered as a potentially malignant condition and could transformed into oral squamous cell carcinoma (OSCC). Squamous cell carcinmoma is the most common oral cancer. This study aimed to compare salivary thioredoxin levels as an antioxidant protein among patients with OSSC, OLP and healthy subjects.
Twenty-eight patients with OLP, 20 patients with OSCC and 40 healthy people enrolled in this observational study. Saliva samples were collected from all subjects and salivary thioredoxin levels were evaluated by Elisa test. The data were recorded in the check lists and analyzed using SPSS (ver.17).
Thioredoxin levels of healthy controls were insignificantly higher than OLP and SCC patients (p = 0.135). There was a statistically remarkable indirect relationship between thioredoxin levels and severity of the lesions determined by Thongprasom criteria among OLP patients. The thioredoxin concentration was significantly higher in the keratotic OLP. Among the OSCC patients, the highest levels of thioredoxin were found among patients aged more than 65 years. Salivary thioredoxin levels based on other variables were not significantly different between the studied groups.
In this study, there was not any significant difference between salivary thioredoxin levels in the OLP and OSCC patients, though it was unremarkable higher in the healthy group compared to the patients; therefore, the role of thioredoxin in the cellular oxidation-reduction status could be suggested; however, further studies are recommended.
口腔扁平苔藓（OLP）是一种慢性黏膜皮肤炎症性疾病，被认为是一种潜在的恶性病变，可能会转化为口腔鳞状细胞癌（OSCC）。鳞状细胞癌是最常见的口腔癌。本研究旨在比较OSCC、OLP患者及健康受试者唾液中作为抗氧化蛋白的硫氧还蛋白水平。
28例OLP患者、20例OSCC患者和40名健康人纳入本观察性研究。收集所有受试者的唾液样本，采用酶联免疫吸附测定（ELISA）试验评估唾液硫氧还蛋白水平。数据记录在检查表中，并使用SPSS（版本17）进行分析。
健康对照组的硫氧还蛋白水平略高于OLP和SCC患者（p = 0.135）。在OLP患者中，根据Thongprasom标准确定，硫氧还蛋白水平与病变严重程度之间存在显著的间接关系。角质化OLP患者的硫氧还蛋白浓度显著更高。在OSCC患者中，65岁以上患者的硫氧还蛋白水平最高。基于其他变量的唾液硫氧还蛋白水平在研究组之间无显著差异。
在本研究中OLP和OSCC患者的唾液硫氧还蛋白水平无显著差异，尽管健康组的该水平略高于患者组；因此，可以认为硫氧还蛋白在细胞氧化还原状态中发挥作用；然而，建议进一步开展研究。
