Department of Biomedical Sciences, Texas A&M Health Science Center-Baylor College of Dentistry, Dallas, Texas 75246, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Aug;114(2):215-22. doi: 10.1016/j.oooo.2012.03.013.
The objective of this study was to gather preliminary data concerning the feasibility of using salivary basic fibroblast growth factor (bFGF) for detecting development of oral squamous cell carcinoma (OSCC) in patients with oral lichen planus (OLP), and in patients with OSCC whose disease was in remission.
Saliva samples were collected from 5 patient groups: patients with newly diagnosed OSCC, patients with OSCC whose disease was in remission, patients with OLP in disease-active state, patients with OLP in disease-inactive state, and healthy controls. Salivary bFGF levels were determined by enzyme-linked immunosorbent assay, and data were analyzed using the Mann-Whitney U test.
Salivary bFGF levels were significantly elevated in patients with newly diagnosed OSCC compared with patients with OSCC in remission, patients with disease-active OLP, and healthy controls. No significant difference was found between patients with newly diagnosed OSCC and patients with disease-inactive OLP.
Our results suggested that salivary bFGF might be a potential biomarker for detecting OSCC development in patients with OSCC in remission, but not in patients with OLP.
本研究旨在收集初步数据，探讨唾液碱性成纤维细胞生长因子（bFGF）用于检测口腔扁平苔藓（OLP）患者和处于缓解期的口腔鳞状细胞癌（OSCC）患者口腔 OSCC 发展的可行性。
收集了 5 组患者的唾液样本：新诊断为 OSCC 的患者、疾病缓解期的 OSCC 患者、活动期 OLP 患者、非活动期 OLP 患者和健康对照组。通过酶联免疫吸附试验测定唾液 bFGF 水平，并采用曼-惠特尼 U 检验对数据进行分析。
与疾病缓解期的 OSCC 患者、活动期 OLP 患者和健康对照组相比，新诊断为 OSCC 的患者唾液 bFGF 水平显著升高。新诊断为 OSCC 的患者与非活动期 OLP 患者之间无显著差异。
我们的研究结果表明，唾液 bFGF 可能是检测缓解期 OSCC 患者 OSCC 发展的潜在生物标志物，但不适用于 OLP 患者。
