School of Chemical Sciences, Mahatma Gandhi University, Priyadarsini Hills P O, Kottayam, Kerala, India 686560.
Org Biomol Chem. 2020 Dec 23;18(48):9775-9790. doi: 10.1039/d0ob02000a.
Quinolines are a predominant class of nitrogen containing heterocycles with wide applications in the medical and industrial fields. Owing to their significant importance, numerous synthetic protocols have emerged in the past two centuries. Metal-free synthesis of quinolines has recently gained attention in view of toxic metal-free druggable quinoline synthesis. In this context, this review focuses on the recent advances in the metal-free synthesis of quinolines and covers all the reports from 2016-2020.
喹啉类化合物是含氮杂环化合物中的主要类别,在医学和工业领域有广泛的应用。由于其重要性,在过去的两个世纪中出现了许多合成方法。鉴于无毒性金属的可药用喹啉合成的重要性,近年来无金属合成喹啉受到了关注。在这种情况下,本文综述了无金属合成喹啉的最新进展,涵盖了 2016 年至 2020 年的所有报道。