COVID-19 会引发炎症小体。
COVID-19 stokes inflammasomes.
机构信息
Departments of Medicine and Veterinary Medicine, The University of Cambridge, Cambridge, UK.
出版信息
J Exp Med. 2021 Mar 1;218(3). doi: 10.1084/jem.20202413.
Abstract
The poor success rate of treating patients with aggressive sepsis in SARS-CoV-2 infections has highlighted again the challenges of managing systemic inflammatory conditions. In this issue of JEM, Rodrigues et al. (https://doi.org/10.1084/jem.20201707) discuss the role of inflammasome activation in COVID-19 disease severity, opening new possibilities for therapeutic management of sepsis syndromes.
摘要
在严重急性呼吸综合征冠状病毒 2 感染患者中，治疗侵袭性败血症患者的成功率较低，这再次凸显了管理全身炎症性疾病的挑战。在本期《实验医学杂志》中，Rodrigues 等人（https://doi.org/10.1084/jem.20201707）讨论了炎症小体激活在 COVID-19 疾病严重程度中的作用，为败血症综合征的治疗管理开辟了新的可能性。
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