Intrahospital Infections Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
FEMS Microbiol Rev. 2021 May 5;45(3). doi: 10.1093/femsre/fuaa054.
Antimicrobial resistance is a major threat to global public health. Vaccination is an effective approach for preventing bacterial infections, however it has not been successfully applied to infections caused by some of the most problematic multidrug resistant pathogens. In this review, the potential for vaccines to contribute to reducing the burden of disease of infections caused by multidrug resistant Gram negative bacteria is presented. Technical, logistical and societal hurdles that have limited successful vaccine development for these infections in the past are identified, and recent advances that can contribute to overcoming these challenges are assessed. A synthesis of vaccine technologies that have been employed in the development of vaccines for key multidrug resistant Gram negative bacteria is included, and emerging technologies that may contribute to future successes are discussed. Finally, a comprehensive review of vaccine development efforts over the last 40 years for three of the most worrisome multidrug resistant Gram negative pathogens, Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa is presented, with a focus on recent and ongoing studies. Finally, future directions for the vaccine development field are highlighted.
抗菌药物耐药性是对全球公共卫生的主要威胁。疫苗接种是预防细菌感染的有效方法，但尚未成功应用于一些最具问题的多药耐药病原体引起的感染。在这篇综述中，介绍了疫苗在减少多药耐药革兰氏阴性菌引起的感染疾病负担方面的潜力。确定了过去限制这些感染疫苗成功开发的技术、后勤和社会障碍，并评估了有助于克服这些挑战的最新进展。综合了用于开发关键多药耐药革兰氏阴性菌疫苗的疫苗技术，并讨论了可能有助于未来成功的新兴技术。最后，全面回顾了过去 40 年来针对三种最令人担忧的多药耐药革兰氏阴性病原体（鲍曼不动杆菌、肺炎克雷伯菌和铜绿假单胞菌）的疫苗开发工作，重点介绍了最近和正在进行的研究。最后，强调了疫苗开发领域的未来发展方向。
