影像学孤立综合征：将微小RNA作为预后生物标志物的研究
Radiologically isolated syndrome: targeting miRNAs as prognostic biomarkers.
作者信息
Muñoz-San Martín María, Torras Sandra, Robles-Cedeño René, Buxó Maria, Gomez Imma, Matute-Blanch Clara, Comabella Manuel, Villar Luisa María, Perkal Héctor, Quintana Ester, Ramió-Torrentà Lluís
机构信息
Neurodegeneration & Neuroinflammation Group, Girona Biomedical Research Institute (IDIBGI), 17190 Salt, Spain.
Department of Neurology, Girona Neuroimmunology & Multiple Sclerosis Unit, Dr. Josep Trueta University Hospital & Santa Caterina Hospital, Girona/Salt-Spain; Neurodegeneration & Neuroinflammation Group, Girona Biomedical Research Institute (IDIBGI), 17190 Salt, Spain.
出版信息
Epigenomics. 2020 Dec;12(23):2065-2076. doi: 10.2217/epi-2020-0172. Epub 2020 Dec 8.
Some clinical and biological characteristics have been described as prognostic factors for clinical conversion into clinically definite multiple sclerosis in radiologically isolated syndrome (RIS) population. The aim of this study was to assess signatures of circulating miRNAs in those patients according to their conversion status after 5 years of follow-up. OpenArray plates assessing 216 miRNA candidates were run in 15 RIS patients, and their relative abundances were analyzed. A specific profile of deregulated circulating miRNAs (miR-144-3p, miR-448 and miR-653-3p in cerebrospinal fluid and miR-142-3p, miR-338-3p, miR-363-3p, miR-374b-5p, miR-424-5p, miR-483-3p in plasma) differentiated individuals who remained as RIS after 5 years of follow-up. Circulating miRNAs might be used as prognostic biomarkers for RIS patients.
一些临床和生物学特征已被描述为放射学孤立综合征（RIS）人群临床转化为临床确诊多发性硬化症的预后因素。本研究的目的是根据这些患者5年随访后的转化状态，评估其循环miRNA的特征。对15例RIS患者进行了评估216种miRNA候选物的OpenArray板检测，并分析了它们的相对丰度。失调的循环miRNA（脑脊液中的miR-144-3p、miR-448和miR-653-3p以及血浆中的miR-142-3p、miR-338-3p、miR-363-3p、miR-374b-5p、miR-424-5p、miR-483-3p）的特定特征区分了5年随访后仍为RIS的个体。循环miRNA可能用作RIS患者的预后生物标志物。
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