Arcas Vasile Calin, Fratila Anca Maria, Moga Doru Florian Cornel, Roman-Filip Iulian, Arcas Ana-Maria Cristina, Roman-Filip Corina, Sava Mihai
Doctoral School, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
J Pers Med. 2024 Jul 31;14(8):815. doi: 10.3390/jpm14080815.
MicroRNA-150 (miR-150) plays a critical role in immune regulation and has been implicated in autoimmune diseases like Multiple Sclerosis (MS). This review aims to evaluate miR-150's potential as a biomarker for MS, necessitating this review to consolidate current evidence and highlight miR-150's utility in improving diagnostic accuracy and monitoring disease progression.
A comprehensive literature search was conducted in databases like PubMed, Scopus, Google Scholar, SciSpace, MDPI and Web of Science, adhering to PRISMA guidelines. Studies focusing on miR-150 implications in MS were included. Data extraction was conducted, while quality assessment was done using the NOS and AMSTAR 2 tools. With the extracted data a statistical analyses conducted.
10 eligible articles were included in review. Findings show that miR-150 levels were consistently deregulated in MS patients compared to healthy controls, correlating with disease severity and clinical parameters such as (EDSS) scores and disease activity. Additionally, miR-150 is implicated in the inflammatory pathogenesis of MS, affecting immune cell regulation and inflammatory pathways.
MiR-150 is a promising biomarker for MS, showing significant potential for improving diagnostic accuracy and monitoring disease progression. Its consistent deregulation in MS patients and correlation with clinical parameters underscore its clinical utility. Further research should validate miR-150's salivary presence and its possible usage as a novel biomarker and therapeutic potential in the development of MS.
微小RNA-150（miR-150）在免疫调节中起关键作用，并与多发性硬化症（MS）等自身免疫性疾病有关。本综述旨在评估miR-150作为MS生物标志物的潜力，为此需要整合当前证据并强调miR-150在提高诊断准确性和监测疾病进展方面的效用。
按照PRISMA指南，在PubMed、Scopus、谷歌学术、SciSpace、MDPI和科学网等数据库中进行了全面的文献检索。纳入了关注miR-150在MS中的影响的研究。进行了数据提取，同时使用NOS和AMSTAR 2工具进行了质量评估。对提取的数据进行了统计分析。
本综述纳入了10篇符合条件的文章。研究结果表明，与健康对照相比，MS患者的miR-150水平持续失调，与疾病严重程度以及扩展残疾状态量表（EDSS）评分和疾病活动等临床参数相关。此外，miR-150与MS的炎症发病机制有关，影响免疫细胞调节和炎症途径。
MiR-150是一种有前景的MS生物标志物，在提高诊断准确性和监测疾病进展方面显示出巨大潜力。其在MS患者中的持续失调以及与临床参数的相关性突出了其临床效用。进一步的研究应验证miR-150在唾液中的存在及其作为新型生物标志物的可能用途以及在MS发展中的治疗潜力。
